| Tag | Content |
|---|
| CPLM ID | CPLM-035011 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | ATP-dependent (S)-NAD(P)H-hydrate dehydratase |
Protein Synonyms/Alias | ATP-dependent NAD(P)HX dehydratase; Carbohydrate kinase domain-containing protein |
Gene Name | Carkd |
Gene Synonyms/Alias | RGD1562691_predicted; rCG_43121 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 47 | IVPALTSKKHKGQDG | acetylation | [1] | | 120 | DAVEEVEKWLPRLHA | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity). |
Sequence Annotation | DOMAIN 33 324 YjeF C-terminal (By similarity).
NP_BIND 226 230 ATP (By similarity).
NP_BIND 245 254 ATP (By similarity).
REGION 186 192 NAD(P)HX (By similarity).
BINDING 133 133 NAD(P)HX; via amide nitrogen (By
BINDING 255 255 NAD(P)HX (By similarity). |
Keyword | ATP-binding; Complete proteome; Lyase; Mitochondrion; NAD; Nucleotide-binding; Phosphoprotein; Reference proteome; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 327 AA |
Protein Sequence | MGIRCVAIRA CGGVLQRALS LHTAHATKDM DNLFQLVRNI VPALTSKKHK GQDGRIGIVG 60
GCQEYTGAPY FAGISALKVG ADLTHVFCAR EAAPVIKSYS PELIVHPVLD SSDAVEEVEK 120
WLPRLHALVV GPGLGRDDLL LNNVRGILES TKARDIPVVI DADGLWLIAQ RPALVHGYQK 180
AVLTPNHVEF SRLWDAVLSS PMDTSNHSGS VLKLSQALGN ITIVQKGEQD LISNGQQVLV 240
CNQEGSSRRC GGQGDLLSGS LGVMAHWALR AGPEKTNGSS PLLVAAWGAC TLTRECNHLA 300
FQKYGRSTTT TDMIAEVGAA FSKLFTT 327 |
Gene Ontology | GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0047453; F:ATP-dependent NAD(P)H-hydrate dehydratase activity; IEA:HAMAP. GO:0046496; P:nicotinamide nucleotide metabolic process; IEA:HAMAP. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |