CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023303
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine/arginine repetitive matrix protein 2 
Protein Synonyms/Alias
 300 kDa nuclear matrix antigen; Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa; SR-related nuclear matrix protein of 300 kDa; Ser/Arg-related nuclear matrix protein of 300 kDa; Splicing coactivator subunit SRm300; Tax-responsive enhancer element-binding protein 803; TaxREB803 
Gene Name
 SRRM2 
Gene Synonyms/Alias
 KIAA0324; SRL300; SRM300; HSPC075 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
37RGERPDYKGEEELRRacetylation[1]
37RGERPDYKGEEELRRubiquitination[2]
51RLEAALVKRPNPDILubiquitination[2]
101FRLMLLEKDVNPGGKubiquitination[2]
108KDVNPGGKEETPGQRubiquitination[2]
169QPAPEPPKPYSLVREacetylation[1]
239PTPKSKRKSKDKKRKmethylation[3]
1186SPPRQKDKFSPFPVQacetylation[1, 4, 5]
1186SPPRQKDKFSPFPVQubiquitination[6, 7]
1223AGSSPETKEQNSALPubiquitination[8]
1244ELMEVVEKSEEPAGQubiquitination[8]
1467SGSSPGMKDIPRTPSacetylation[1, 4, 5]
1588SSPEVDSKSRLSPRRmethylation[3]
2602PPEPTPAKRKRRSSSacetylation[5]
2680RRSRSPRKPIDSLRDubiquitination[9]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Mass spectrometry-based identification and characterisation of lysine and arginine methylation in the human proteome.
 Bremang M, Cuomo A, Agresta AM, Stugiewicz M, Spadotto V, Bonaldi T.
 Mol Biosyst. 2013 Jul 30;9(9):2231-47. [PMID: 23748837]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [7] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [8] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [9] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity). Binds to RNA. 
Sequence Annotation
 REGION 197 259 Sufficient for RNA-binding.
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 24 24 Phosphoserine.
 MOD_RES 145 145 Phosphotyrosine.
 MOD_RES 169 169 N6-acetyllysine.
 MOD_RES 220 220 Phosphoserine.
 MOD_RES 222 222 Phosphoserine.
 MOD_RES 286 286 Phosphothreonine.
 MOD_RES 295 295 Phosphoserine.
 MOD_RES 297 297 Phosphoserine.
 MOD_RES 300 300 Phosphoserine.
 MOD_RES 322 322 Phosphoserine.
 MOD_RES 323 323 Phosphoserine.
 MOD_RES 333 333 Phosphoserine.
 MOD_RES 351 351 Phosphoserine.
 MOD_RES 353 353 Phosphoserine.
 MOD_RES 357 357 Phosphoserine.
 MOD_RES 358 358 Phosphoserine.
 MOD_RES 359 359 Phosphothreonine.
 MOD_RES 367 367 Phosphothreonine.
 MOD_RES 377 377 Phosphoserine.
 MOD_RES 387 387 Phosphoserine.
 MOD_RES 398 398 Phosphoserine.
 MOD_RES 404 404 Phosphoserine.
 MOD_RES 408 408 Phosphoserine.
 MOD_RES 424 424 Phosphoserine.
 MOD_RES 435 435 Phosphoserine.
 MOD_RES 436 436 Phosphoserine (By similarity).
 MOD_RES 437 437 Phosphoserine (By similarity).
 MOD_RES 440 440 Phosphoserine.
 MOD_RES 454 454 Phosphoserine.
 MOD_RES 472 472 Phosphoserine (By similarity).
 MOD_RES 474 474 Phosphoserine (By similarity).
 MOD_RES 484 484 Phosphoserine.
 MOD_RES 486 486 Phosphoserine.
 MOD_RES 534 534 Phosphoserine (By similarity).
 MOD_RES 536 536 Phosphoserine (By similarity).
 MOD_RES 625 625 Phosphoserine (By similarity).
 MOD_RES 627 627 Phosphothreonine (By similarity).
 MOD_RES 629 629 Phosphoserine (By similarity).
 MOD_RES 778 778 Phosphoserine.
 MOD_RES 780 780 Phosphoserine.
 MOD_RES 783 783 Phosphoserine.
 MOD_RES 846 846 Phosphoserine.
 MOD_RES 848 848 Phosphothreonine (By similarity).
 MOD_RES 857 857 Phosphoserine.
 MOD_RES 864 864 Phosphoserine.
 MOD_RES 866 866 Phosphothreonine.
 MOD_RES 871 871 Phosphoserine.
 MOD_RES 875 875 Phosphoserine.
 MOD_RES 876 876 Phosphoserine.
 MOD_RES 908 908 Phosphoserine.
 MOD_RES 924 924 Phosphoserine.
 MOD_RES 950 950 Phosphoserine.
 MOD_RES 952 952 Phosphoserine.
 MOD_RES 954 954 Phosphoserine.
 MOD_RES 957 957 Phosphoserine.
 MOD_RES 968 968 Phosphoserine.
 MOD_RES 970 970 Phosphoserine.
 MOD_RES 972 972 Phosphoserine.
 MOD_RES 973 973 Phosphoserine.
 MOD_RES 974 974 Phosphoserine.
 MOD_RES 977 977 Phosphothreonine.
 MOD_RES 983 983 Phosphothreonine.
 MOD_RES 992 992 Phosphoserine.
 MOD_RES 994 994 Phosphoserine.
 MOD_RES 1003 1003 Phosphothreonine.
 MOD_RES 1014 1014 Phosphoserine.
 MOD_RES 1028 1028 Phosphoserine.
 MOD_RES 1032 1032 Phosphoserine.
 MOD_RES 1043 1043 Phosphothreonine.
 MOD_RES 1064 1064 Phosphoserine.
 MOD_RES 1069 1069 Phosphoserine.
 MOD_RES 1072 1072 Phosphoserine.
 MOD_RES 1073 1073 Phosphoserine.
 MOD_RES 1083 1083 Phosphoserine.
 MOD_RES 1099 1099 Phosphoserine.
 MOD_RES 1101 1101 Phosphoserine.
 MOD_RES 1102 1102 Phosphoserine.
 MOD_RES 1103 1103 Phosphoserine.
 MOD_RES 1106 1106 Phosphothreonine.
 MOD_RES 1112 1112 Phosphoserine.
 MOD_RES 1122 1122 Phosphoserine.
 MOD_RES 1124 1124 Phosphoserine.
 MOD_RES 1129 1129 Phosphoserine.
 MOD_RES 1132 1132 Phosphoserine.
 MOD_RES 1152 1152 Phosphoserine.
 MOD_RES 1179 1179 Phosphoserine.
 MOD_RES 1188 1188 Phosphoserine.
 MOD_RES 1208 1208 Phosphothreonine.
 MOD_RES 1214 1214 Phosphoserine.
 MOD_RES 1219 1219 Phosphoserine.
 MOD_RES 1257 1257 Phosphoserine (By similarity).
 MOD_RES 1318 1318 Phosphoserine.
 MOD_RES 1320 1320 Phosphoserine.
 MOD_RES 1326 1326 Phosphoserine.
 MOD_RES 1329 1329 Phosphoserine.
 MOD_RES 1336 1336 Phosphoserine.
 MOD_RES 1348 1348 Phosphoserine (By similarity).
 MOD_RES 1368 1368 Phosphoserine.
 MOD_RES 1378 1378 Phosphoserine (By similarity).
 MOD_RES 1382 1382 Phosphoserine.
 MOD_RES 1383 1383 Phosphoserine (By similarity).
 MOD_RES 1384 1384 Phosphoserine (By similarity).
 MOD_RES 1387 1387 Phosphoserine.
 MOD_RES 1401 1401 Phosphoserine.
 MOD_RES 1403 1403 Phosphoserine.
 MOD_RES 1404 1404 Phosphoserine.
 MOD_RES 1413 1413 Phosphothreonine.
 MOD_RES 1415 1415 Phosphoserine.
 MOD_RES 1419 1419 Phosphoserine (By similarity).
 MOD_RES 1420 1420 Phosphoserine (By similarity).
 MOD_RES 1421 1421 Phosphoserine.
 MOD_RES 1424 1424 Phosphoserine.
 MOD_RES 1434 1434 Phosphothreonine.
 MOD_RES 1444 1444 Phosphoserine.
 MOD_RES 1451 1451 Phosphoserine.
 MOD_RES 1453 1453 Phosphothreonine.
 MOD_RES 1458 1458 Phosphoserine.
 MOD_RES 1460 1460 Phosphoserine.
 MOD_RES 1462 1462 Phosphoserine.
 MOD_RES 1463 1463 Phosphoserine.
 MOD_RES 1472 1472 Phosphothreonine.
 MOD_RES 1478 1478 Phosphoserine (By similarity).
 MOD_RES 1482 1482 Phosphoserine.
 MOD_RES 1483 1483 Phosphoserine.
 MOD_RES 1492 1492 Phosphothreonine.
 MOD_RES 1497 1497 Phosphoserine.
 MOD_RES 1499 1499 Phosphoserine.
 MOD_RES 1501 1501 Phosphoserine.
 MOD_RES 1502 1502 Phosphoserine.
 MOD_RES 1511 1511 Phosphothreonine.
 MOD_RES 1517 1517 Phosphoserine.
 MOD_RES 1519 1519 Phosphoserine.
 MOD_RES 1521 1521 Phosphoserine.
 MOD_RES 1522 1522 Phosphoserine.
 MOD_RES 1531 1531 Phosphothreonine.
 MOD_RES 1537 1537 Phosphoserine.
 MOD_RES 1539 1539 Phosphoserine.
 MOD_RES 1541 1541 Phosphoserine.
 MOD_RES 1542 1542 Phosphoserine.
 MOD_RES 1552 1552 Phosphoserine.
 MOD_RES 1557 1557 Phosphoserine (By similarity).
 MOD_RES 1559 1559 Phosphoserine (By similarity).
 MOD_RES 1577 1577 Phosphoserine.
 MOD_RES 1579 1579 Phosphoserine.
 MOD_RES 1581 1581 Phosphoserine.
 MOD_RES 1582 1582 Phosphoserine.
 MOD_RES 1589 1589 Phosphoserine (By similarity).
 MOD_RES 1592 1592 Phosphoserine (By similarity).
 MOD_RES 1596 1596 Phosphoserine (By similarity).
 MOD_RES 1598 1598 Phosphoserine.
 MOD_RES 1600 1600 Phosphoserine.
 MOD_RES 1601 1601 Phosphoserine.
 MOD_RES 1616 1616 Phosphoserine (By similarity).
 MOD_RES 1620 1620 Phosphoserine (By similarity).
 MOD_RES 1621 1621 Phosphoserine.
 MOD_RES 1648 1648 Phosphoserine.
 MOD_RES 1658 1658 Phosphoserine.
 MOD_RES 1675 1675 Phosphoserine (By similarity).
 MOD_RES 1691 1691 Phosphoserine.
 MOD_RES 1693 1693 Phosphoserine.
 MOD_RES 1694 1694 Phosphoserine.
 MOD_RES 1698 1698 Phosphothreonine.
 MOD_RES 1727 1727 Phosphoserine.
 MOD_RES 1729 1729 Phosphoserine.
 MOD_RES 1731 1731 Phosphoserine.
 MOD_RES 1732 1732 Phosphoserine.
 MOD_RES 1762 1762 Phosphoserine.
 MOD_RES 1764 1764 Phosphoserine.
 MOD_RES 1791 1791 Phosphoserine (By similarity).
 MOD_RES 1793 1793 Phosphoserine (By similarity).
 MOD_RES 1818 1818 Phosphoserine.
 MOD_RES 1822 1822 Phosphoserine.
 MOD_RES 1842 1842 Phosphoserine (By similarity).
 MOD_RES 1844 1844 Phosphothreonine (By similarity).
 MOD_RES 1854 1854 Phosphoserine.
 MOD_RES 1857 1857 Phosphoserine.
 MOD_RES 1866 1866 Phosphoserine (By similarity).
 MOD_RES 1876 1876 Phosphoserine.
 MOD_RES 1878 1878 Phosphoserine.
 MOD_RES 1880 1880 Phosphothreonine.
 MOD_RES 1884 1884 Phosphoserine.
 MOD_RES 1888 1888 Phosphoserine (By similarity).
 MOD_RES 1890 1890 Phosphoserine.
 MOD_RES 1892 1892 Phosphothreonine.
 MOD_RES 1893 1893 Phosphoserine.
 MOD_RES 1911 1911 Phosphoserine (By similarity).
 MOD_RES 1913 1913 Phosphoserine (By similarity).
 MOD_RES 1916 1916 Phosphoserine.
 MOD_RES 1919 1919 Phosphoserine.
 MOD_RES 1923 1923 Phosphoserine.
 MOD_RES 1925 1925 Phosphoserine.
 MOD_RES 1927 1927 Phosphothreonine.
 MOD_RES 1931 1931 Phosphothreonine.
 MOD_RES 1946 1946 Phosphoserine.
 MOD_RES 1948 1948 Phosphoserine.
 MOD_RES 1950 1950 Phosphothreonine.
 MOD_RES 1954 1954 Phosphothreonine.
 MOD_RES 1958 1958 Phosphoserine.
 MOD_RES 1960 1960 Phosphoserine.
 MOD_RES 1962 1962 Phosphothreonine.
 MOD_RES 1966 1966 Phosphothreonine.
 MOD_RES 1970 1970 Phosphoserine.
 MOD_RES 1972 1972 Phosphoserine.
 MOD_RES 1975 1975 Phosphoserine.
 MOD_RES 1978 1978 Phosphothreonine.
 MOD_RES 1984 1984 Phosphoserine.
 MOD_RES 1987 1987 Phosphoserine.
 MOD_RES 1996 1996 Phosphoserine.
 MOD_RES 1999 1999 Phosphoserine.
 MOD_RES 2006 2006 Phosphoserine (By similarity).
 MOD_RES 2008 2008 Phosphoserine.
 MOD_RES 2010 2010 Phosphothreonine (By similarity).
 MOD_RES 2011 2011 Phosphoserine.
 MOD_RES 2020 2020 Phosphoserine.
 MOD_RES 2022 2022 Phosphothreonine.
 MOD_RES 2030 2030 Phosphoserine (By similarity).
 MOD_RES 2032 2032 Phosphoserine.
 MOD_RES 2034 2034 Phosphothreonine.
 MOD_RES 2042 2042 Phosphoserine (By similarity).
 MOD_RES 2044 2044 Phosphoserine.
 MOD_RES 2046 2046 Phosphoserine.
 MOD_RES 2067 2067 Phosphoserine.
 MOD_RES 2069 2069 Phosphothreonine.
 MOD_RES 2071 2071 Phosphoserine.
 MOD_RES 2090 2090 Phosphoserine.
 MOD_RES 2092 2092 Phosphothreonine.
 MOD_RES 2100 2100 Phosphoserine.
 MOD_RES 2102 2102 Phosphoserine.
 MOD_RES 2104 2104 Phosphothreonine.
 MOD_RES 2118 2118 Phosphoserine.
 MOD_RES 2121 2121 Phosphoserine.
 MOD_RES 2123 2123 Phosphoserine.
 MOD_RES 2132 2132 Phosphoserine.
 MOD_RES 2144 2144 Phosphothreonine.
 MOD_RES 2272 2272 Phosphoserine.
 MOD_RES 2289 2289 Phosphothreonine.
 MOD_RES 2291 2291 Phosphothreonine.
 MOD_RES 2302 2302 Phosphothreonine.
 MOD_RES 2316 2316 Phosphothreonine.
 MOD_RES 2329 2329 Phosphothreonine.
 MOD_RES 2335 2335 Phosphoserine.
 MOD_RES 2343 2343 Phosphoserine.
 MOD_RES 2381 2381 Phosphothreonine.
 MOD_RES 2382 2382 Phosphoserine.
 MOD_RES 2394 2394 Phosphoserine.
 MOD_RES 2398 2398 Phosphoserine.
 MOD_RES 2407 2407 Phosphoserine.
 MOD_RES 2409 2409 Phosphothreonine.
 MOD_RES 2412 2412 Phosphoserine.
 MOD_RES 2415 2415 Phosphoserine.
 MOD_RES 2426 2426 Phosphoserine.
 MOD_RES 2429 2429 Phosphoserine.
 MOD_RES 2449 2449 Phosphoserine.
 MOD_RES 2453 2453 Phosphoserine.
 MOD_RES 2581 2581 Phosphoserine.
 MOD_RES 2583 2583 Phosphothreonine.
 MOD_RES 2664 2664 Phosphoserine.
 MOD_RES 2675 2675 Phosphoserine.
 MOD_RES 2677 2677 Phosphoserine.
 MOD_RES 2684 2684 Phosphoserine.
 MOD_RES 2688 2688 Phosphoserine.
 MOD_RES 2690 2690 Phosphoserine.
 MOD_RES 2692 2692 Phosphoserine.
 MOD_RES 2693 2693 Phosphotyrosine (By similarity).
 MOD_RES 2694 2694 Phosphoserine.
 MOD_RES 2702 2702 Phosphoserine.
 MOD_RES 2706 2706 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Coiled coil; Complete proteome; Direct protein sequencing; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; RNA-binding; Spliceosome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2752 AA 
Protein Sequence
MYNGIGLPTP RGSGTNGYVQ RNLSLVRGRR GERPDYKGEE ELRRLEAALV KRPNPDILDH 60
ERKRRVELRC LELEEMMEEQ GYEEQQIQEK VATFRLMLLE KDVNPGGKEE TPGQRPAVTE 120
THQLAELNEK KNERLRAAFG ISDSYVDGSS FDPQRRAREA KQPAPEPPKP YSLVRESSSS 180
RSPTPKQKKK KKKKDRGRRS ESSSPRRERK KSSKKKKHRS ESESKKRKHR SPTPKSKRKS 240
KDKKRKRSRS TTPAPKSRRA HRSTSADSAS SSDTSRSRSR SAAAKTHTTA LAGRSPSPAS 300
GRRGEGDAPF SEPGTTSTQR PSSPETATKQ PSSPYEDKDK DKKEKSATRP SPSPERSSTG 360
PEPPAPTPLL AERHGGSPQP LATTPLSQEP VNPPSEASPT RDRSPPKSPE KLPQSSSSES 420
SPPSPQPTKV SRHASSSPES PKPAPAPGSH REISSSPTSK NRSHGRAKRD KSHSHTPSRR 480
MGRSRSPATA KRGRSRSRTP TKRGHSRSRS PQWRRSRSAQ RWGRSRSPQR RGRSRSPQRP 540
GWSRSRNTQR RGRSRSARRG RSHSRSPATR GRSRSRTPAR RGRSRSRTPA RRRSRSRTPT 600
RRRSRSRTPA RRGRSRSRTP ARRRSRTRSP VRRRSRSRSP ARRSGRSRSR TPARRGRSRS 660
RTPARRGRSR SRTPARRSGR SRSRTPARRG RSRSRTPRRG RSRSRSLVRR GRSHSRTPQR 720
RGRSGSSSER KNKSRTSQRR SRSNSSPEMK KSRISSRRSR SLSSPRSKAK SRLSLRRSLS 780
GSSPCPKQKS QTPPRRSRSG SSQPKAKSRT PPRRSRSSSS PPPKQKSKTP SRQSHSSSSP 840
HPKVKSGTPP RQGSITSPQA NEQSVTPQRR SCFESSPDPE LKSRTPSRHS CSGSSPPRVK 900
SSTPPRQSPS RSSSPQPKVK AIISPRQRSH SGSSSPSPSR VTSRTTPRRS RSVSPCSNVE 960
SRLLPRYSHS GSSSPDTKVK PETPPRQSHS GSISPYPKVK AQTPPGPSLS GSKSPCPQEK 1020
SKDSLVQSCP GSLSLCAGVK SSTPPGESYF GVSSLQLKGQ SQTSPDHRSD TSSPEVRQSH 1080
SESPSLQSKS QTSPKGGRSR SSSPVTELAS RSPIRQDRGE FSASPMLKSG MSPEQSRFQS 1140
DSSSYPTVDS NSLLGQSRLE TAESKEKMAL PPQEDATASP PRQKDKFSPF PVQDRPESSL 1200
VFKDTLRTPP RERSGAGSSP ETKEQNSALP TSSQDEELME VVEKSEEPAG QILSHLSSEL 1260
KEMSTSNFES SPEVEERPAV SLTLDQSQSQ ASLEAVEVPS MASSWGGPHF SPEHKELSNS 1320
PLRENSFGSP LEFRNSGPLG TEMNTGFSSE VKEDLNGPFL NQLETDPSLD MKEQSTRSSG 1380
HSSSELSPDA VEKAGMSSNQ SISSPVLDAV PRTPSRERSS SASSPEMKDG LPRTPSRRSR 1440
SGSSPGLRDG SGTPSRHSLS GSSPGMKDIP RTPSRGRSEC DSSPEPKALP QTPRPRSRSP 1500
SSPELNNKCL TPQRERSGSE SSVDQKTVAR TPLGQRSRSG SSQELDVKPS ASPQERSESD 1560
SSPDSKAKTR TPLRQRSRSG SSPEVDSKSR LSPRRSRSGS SPEVKDKPRA APRAQSGSDS 1620
SPEPKAPAPR ALPRRSRSGS SSKGRGPSPE GSSSTESSPE HPPKSRTARR GSRSSPEPKT 1680
KSRTPPRRRS SRSSPELTRK ARLSRRSRSA SSSPETRSRT PPRHRRSPSV SSPEPAEKSR 1740
SSRRRRSASS PRTKTTSRRG RSPSPKPRGL QRSRSRSRRE KTRTTRRRDR SGSSQSTSRR 1800
RQRSRSRSRV TRRRRGGSGY HSRSPARQES SRTSSRRRRG RSRTPPTSRK RSRSRTSPAP 1860
WKRSRSRASP ATHRRSRSRT PLISRRRSRS RTSPVSRRRS RSRTSVTRRR SRSRASPVSR 1920
RRSRSRTPPV TRRRSRSRTP TTRRRSRSRT PPVTRRRSRS RTPPVTRRRS RSRTSPITRR 1980
RSRSRTSPVT RRRSRSRTSP VTRRRSRSRT SPVTRRRSRS RTPPAIRRRS RSRTPLLPRK 2040
RSRSRSPLAI RRRSRSRTPR TARGKRSLTR SPPAIRRRSA SGSSSDRSRS ATPPATRNHS 2100
GSRTPPVALN SSRMSCFSRP SMSPTPLDRC RSPGMLEPLG SSRTPMSVLQ QAGGSMMDGP 2160
GPRIPDHQRT SVPENHAQSR IALALTAISL GTARPPPSMS AAGLAARMSQ VPAPVPLMSL 2220
RTAPAANLAS RIPAASAAAM NLASARTPAI PTAVNLADSR TPAAAAAMNL ASPRTAVAPS 2280
AVNLADPRTP TAPAVNLAGA RTPAALAALS LTGSGTPPTA ANYPSSSRTP QAPASANLVG 2340
PRSAHATAPV NIAGSRTAAA LAPASLTSAR MAPALSGANL TSPRVPLSAY ERVSGRTSPP 2400
LLDRARSRTP PSAPSQSRMT SERAPSPSSR MGQAPSQSLL PPAQDQPRSP VPSAFSDQSR 2460
CLIAQTTPVA GSQSLSSGAV ATTTSSAGDH NGMLSVPAPG VPHSDVGEPP ASTGAQQPSA 2520
LAALQPAKER RSSSSSSSSS SSSSSSSSSS SSSSSSGSSS SDSEGSSLPV QPEVALKRVP 2580
SPTPAPKEAV REGRPPEPTP AKRKRRSSSS SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS 2640
SSSSSSSSPS PAKPGPQALP KPASPKKPPP GERRSRSPRK PIDSLRDSRS LSYSPVERRR 2700
PSPQPSPRDQ QSSSSERGSR RGQRGDSRSP SHKRRRETPS PRPMRHRSSR SP 2752 
Gene Ontology
 GO:0015030; C:Cajal body; IDA:UniProtKB.
 GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB.
 GO:0016607; C:nuclear speck; IDA:UniProtKB.
 GO:0070742; F:C2H2 zinc finger domain binding; IDA:UniProtKB.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0000398; P:mRNA splicing, via spliceosome; IC:UniProtKB. 
Interpro
 IPR013170; mRNA_splic_Cwf21.
 IPR024945; Spt5_C_dom. 
Pfam
 PF08312; cwf21 
SMART
 SM01104; CTD 
PROSITE
  
PRINTS