| Tag | Content |
|---|
| CPLM ID | CPLM-012978 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | F-actin-capping protein subunit alpha-2 |
Protein Synonyms/Alias | CapZ alpha-2 |
Gene Name | Capza2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 86 | HGDLGNGKFLDPKNR | acetylation | [1] | | 97 | PKNRICFKFDHLRKE | acetylation | [1] | | 226 | SNEVQTAKEFIKIVE | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity). |
Sequence Annotation | MOD_RES 2 2 N-acetylalanine. |
Keyword | 3D-structure; Acetylation; Actin capping; Actin-binding; Complete proteome; Direct protein sequencing; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 286 AA |
Protein Sequence | MADLEEQLSD EEKVRIAAKF IIHAPPGEFN EVFNDVRLLL NNDNLLREGA AHAFAQYNLD 60
QFTPVKIEGY EDQVLITEHG DLGNGKFLDP KNRICFKFDH LRKEATDPRP YEAENAIESW 120
RTSVETALRA YVKEHYPNGV CTVYGKKVDG QQTIIACIES HQFQAKNFWN GRWRSEWKFT 180
VTPSTTQVVG ILKIQVHYYE DGNVQLVSHK DIQDSLTVSN EVQTAKEFIK IVEAAENEYQ 240
TAISENYQTM SDTTFKALRR QLPVTRTKID WNKILSYKIG KEMQNA 286 |
Gene Ontology | GO:0030863; C:cortical cytoskeleton; IEA:Compara. GO:0008290; C:F-actin capping protein complex; IEA:InterPro. GO:0016020; C:membrane; IEA:Compara. GO:0030036; P:actin cytoskeleton organization; IEA:InterPro. GO:0051693; P:actin filament capping; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |