CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018814
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Synapsin-2 
Protein Synonyms/Alias
 Synapsin II 
Gene Name
 SYN2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
441QPQSGTLKDPDSSKTubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release (By similarity). 
Sequence Annotation
 REGION 1 29 A.
 REGION 33 112 B; linker.
 REGION 113 420 C; actin-binding and synaptic-vesicle
 REGION 421 457 G; Pro-rich linker.
 REGION 458 533 H; Pro/Ser-rich linker.
 REGION 534 582 E.
 MOD_RES 10 10 Phosphoserine; by PKA and CaMK1 (By
 MOD_RES 421 421 Phosphothreonine (By similarity).
 MOD_RES 425 425 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Cell junction; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome; Synapse. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 582 AA 
Protein Sequence
MMNFLRRRLS DSSFIANLPN GYMTDLQRPE PQQAPTPPPP GPGAASASAA PPTASPGPER 60
TPPAASAPAP PPARTPSVGS SLFSSLSQAV KQTAASAGLV DAPGAAPAAA RKAKVLLVVD 120
EPHADWAKCF RGKKVLGDYD IKVEQAEFSE LNLVAHADGT YAVDMQVLRN GTKVVRSFRP 180
DFVLIRQHAF GMAENEDFRH LIIGMQYAGL PSINSLESIY NFCDKPWVFA QLVAIYKTLG 240
GEKFPLIEQT YYPNHKEMLT LPTFPVVVKI GHAHSGMGKV KVENHYDFQD IASVVALTQT 300
YATAEPFIDS KYDIRVQKIG NNYKAYMRTS ISGNWKTNTG SAMLEQIAMS DRYKLWVDTC 360
SEMFGGLDIC AVKAVHGKDG KDYIFEVMDC SMPLIGEHQV EDRQLITELV ISKMNQLLSR 420
TPALSPQRPL TTQQPQSGTL KDPDSSKTPP QRPPPQGGPG QPQGMQPPGK VLPPRRLPPG 480
PSLPPSSSSS SSSSSSAPQR PGGPTTHGDA PSSSSSLAEA QPPLAAPPQK PQPHPQLNKS 540
QSLTNAFSFS ESSFFRSSAN EDEAKAETIR SLRKSFASLF SD 582 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0008021; C:synaptic vesicle; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0003824; F:catalytic activity; IEA:InterPro.
 GO:0008152; P:metabolic process; IEA:GOC.
 GO:0007269; P:neurotransmitter secretion; IEA:InterPro.
 GO:0007268; P:synaptic transmission; TAS:ProtInc. 
Interpro
 IPR013815; ATP_grasp_subdomain_1.
 IPR013816; ATP_grasp_subdomain_2.
 IPR016185; PreATP-grasp_dom.
 IPR001359; Synapsin.
 IPR020898; Synapsin_ATP-bd_dom.
 IPR019735; Synapsin_CS.
 IPR019736; Synapsin_P_site.
 IPR020897; Synapsin_pre-ATP-grasp_dom. 
Pfam
 PF02078; Synapsin
 PF02750; Synapsin_C
 PF10581; Synapsin_N 
SMART
  
PROSITE
 PS00415; SYNAPSIN_1
 PS00416; SYNAPSIN_2 
PRINTS
 PR01368; SYNAPSIN.