CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016999
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Centrosomal protein of 97 kDa 
Protein Synonyms/Alias
 Cep97; Leucine-rich repeat and IQ domain-containing protein 2 
Gene Name
 CEP97 
Gene Synonyms/Alias
 LRRIQ2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
45IHTLILDKNQIIKLEubiquitination[1]
241DGYVISQKESLKAEWubiquitination[1]
552SVALGQDKVALQKLNubiquitination[1]
557QDKVALQKLNDAATKubiquitination[1]
564KLNDAATKLQACWRGubiquitination[1]
582RNYNPQAKDVRYEIRubiquitination[1]
617ERDEERIKKFVQEEAubiquitination[1]
618RDEERIKKFVQEEAFubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome. 
Sequence Annotation
 REPEAT 37 58 LRR 1.
 REPEAT 59 80 LRR 2.
 REPEAT 81 102 LRR 3.
 REPEAT 103 124 LRR 4.
 REPEAT 125 146 LRR 5.
 REPEAT 147 168 LRR 6.
 REPEAT 171 192 LRR 7.
 REPEAT 196 205 LRR 8.
 DOMAIN 211 249 LRRCT.
 DOMAIN 558 587 IQ.
 REGION 300 750 CCP110-binding.
 MOD_RES 308 308 Phosphoserine.
 MOD_RES 314 314 Phosphoserine.
 MOD_RES 413 413 Phosphoserine.
 MOD_RES 763 763 Phosphoserine.  
Keyword
 Alternative splicing; Calmodulin-binding; Cilium biogenesis/degradation; Complete proteome; Cytoplasm; Cytoskeleton; Leucine-rich repeat; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 865 AA 
Protein Sequence
MAVARVDAAL PPGEGSVVNW SGQGLQKLGP NLPCEADIHT LILDKNQIIK LENLEKCKRL 60
IQLSVANNRL VRMMGVAKLT LLRVLNLPHN SIGCVEGLKE LVHLEWLNLA GNNLKAMEQI 120
NSCTALQHLD LSDNNISQIG DLSKLVSLKT LLLHGNIITS LRMAPAYLPR SLAILSLAEN 180
EIRDLNEISF LASLTELEQL SIMNNPCVMA TPSIPGFDYR PYIVSWCLNL RVLDGYVISQ 240
KESLKAEWLY SQGKGRAYRP GQHIQLVQYL ATVCPLTSTL GLQTAEDAKL EKILSKQRFH 300
QRQLMNQSQN EELSPLVPVE TRASLIPEHS SPVQDCQISQ ESEPVIQVNS WVGINSNDDQ 360
LFAVKNNFPA SVHTTRYSRN DLHLEDIQTD EDKLNCSLLS SESTFMPVAS GLSPLSPTVE 420
LRLQGINLGL EDDGVADESV KGLESQVLDK EEEQPLWAAN ENSVQMMRSE INTEVNEKAG 480
LLPCPEPTII SAILKDDNHS LTFFPESTEQ KQSDIKKPEN TQPENKETIS QATSEKLPMI 540
LTQRSVALGQ DKVALQKLND AATKLQACWR GFYARNYNPQ AKDVRYEIRL RRMQEHIVCL 600
TDEIRRLRKE RDEERIKKFV QEEAFRFLWN QKWGLAILPR PVSNFWAQAV FPPQPPKVRS 660
LQVWQQTVDQ RLSSWHTDVP PISSTLVPSK HPLFTQSQES SCDQNADWFI ASDVAPQEKS 720
LPEFPDSGFH SSLTEQVHSL QHSLDFEKSS TEGSESSIMG NSIDTVRYGK ESDLGDVSEE 780
HGEWNKESSN NEQDNSLLEQ YLTSVQQLED ADERTNFDTE TRDSKLHIAC FPVQLDTLSD 840
GASVDESHGI SPPLQGEISQ TQENSKLNAE VQGQQPECDS TFQLLHVGVT V 891 
Gene Ontology
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0030030; P:cell projection organization; IEA:UniProtKB-KW. 
Interpro
 IPR000048; IQ_motif_EF-hand-BS.
 IPR001611; Leu-rich_rpt.
 IPR025875; Leu-rich_rpt_4. 
Pfam
 PF12799; LRR_4 
SMART
 SM00015; IQ 
PROSITE
 PS50096; IQ
 PS51450; LRR 
PRINTS