| Tag | Content |
|---|
| CPLM ID | CPLM-024317 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Integrin beta-4 |
Protein Synonyms/Alias | CD104 |
Gene Name | Itgb4 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 664 | VKMVDELKKAEEVVE | acetylation | [1] |
|
Reference | [1] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation. Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ. J Biol Chem. 2013 Jul 17;. [ PMID: 23864654] |
Functional Description | Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility (By similarity). |
Sequence Annotation | DOMAIN 30 74 PSI.
DOMAIN 132 310 VWFA.
REPEAT 458 504 I.
REPEAT 505 544 II.
REPEAT 545 583 III.
REPEAT 584 621 IV.
DOMAIN 981 1086 Calx-beta.
DOMAIN 1128 1217 Fibronectin type-III 1.
DOMAIN 1222 1320 Fibronectin type-III 2.
DOMAIN 1524 1614 Fibronectin type-III 3.
DOMAIN 1637 1730 Fibronectin type-III 4.
REGION 458 621 Cysteine-rich tandem repeats.
MOTIF 473 475 Cell attachment site (Potential).
MOTIF 1005 1007 Cell attachment site (Potential).
MOD_RES 1526 1526 Phosphothreonine (By similarity).
CARBOHYD 328 328 N-linked (GlcNAc...) (Potential).
CARBOHYD 493 493 N-linked (GlcNAc...) (Potential).
CARBOHYD 581 581 N-linked (GlcNAc...) (Potential).
CARBOHYD 619 619 N-linked (GlcNAc...) (Potential).
CARBOHYD 697 697 N-linked (GlcNAc...) (Potential).
DISULFID 31 457 By similarity.
DISULFID 39 49 By similarity.
DISULFID 42 73 By similarity.
DISULFID 52 62 By similarity.
DISULFID 246 289 By similarity.
DISULFID 425 673 By similarity.
DISULFID 454 459 By similarity.
DISULFID 470 481 By similarity.
DISULFID 478 514 By similarity.
DISULFID 483 492 By similarity.
DISULFID 494 505 By similarity.
DISULFID 520 525 By similarity.
DISULFID 522 553 By similarity.
DISULFID 527 538 By similarity.
DISULFID 559 564 By similarity.
DISULFID 566 575 By similarity.
DISULFID 577 584 By similarity.
DISULFID 598 603 By similarity.
DISULFID 600 650 By similarity.
DISULFID 605 616 By similarity.
DISULFID 628 637 By similarity.
DISULFID 634 708 By similarity.
DISULFID 653 682 By similarity. |
Keyword | Alternative splicing; Cell adhesion; Cell junction; Complete proteome; Disulfide bond; Glycoprotein; Integrin; Membrane; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1818 AA |
Protein Sequence | MAGPCCSPWV KLLLLAAMLS ASLPGDLANR CKKAQVKSCT ECIRVDKSCA YCTDELFKER 60
RCNTQAELLA AGCRGESILV MESSLEITEN TQIDTSLHRS QVSPQGLQVR LRPGEERSFV 120
FQVFEPLESP VDLYILMDFS NSMSDDLDNL KQMGQNLAKI LRQLTSDYTI GFGKFVDKVS 180
VPQTDMRPEK LKEPWPNSDP PFSFKNVISL TENVEEFWNK LQGERISGNL DAPEGGFDAI 240
LQTAVCTRDI GWRADSTHLL VFSTESAFHY EADGANVLAG IMNRNDEKCH LDASGAYTQY 300
KTQDYPSVPT LVRLLAKHNI IPIFAVTNYS YSYYEKLHKY FPVSSLGVLQ EDSSNIVELL 360
EEAFYRIRSN LDIRALDSPR GLRTEVTSDT LQKTETGSFH IKRGEVGTYN VHLRAVEDID 420
GTHVCQLAKE DQGGNIHLKP SFSDGLRMDA SVICDVCPCE LQKEVRSARC HFRGDFMCGH 480
CVCNEGWSGK TCNCSTGSLS DTQPCLREGE DKPCSGHGEC QCGRCVCYGE GRYEGHFCEY 540
DNFQCPRTSG FLCNDRGRCS MGECVCEPGW TGRSCDCPLS NATCIDSNGG ICNGRGYCEC 600
GRCHCNQQSL YTDTTCEINY SAIRLGLCED LRSCVQCQAW GTGEKKGRAC DDCPFKVKMV 660
DELKKAEEVV EYCSFRDEDD DCTYSYNVEG DGSPGPNSTV LVHKKKDCPP GSFWWLIPLL 720
IFLLLLLALL LLLCWKYCAC CKACLGLLPC CNRGHMVGFK EDHYMLRENL MASDHLDTPM 780
LRSGNLKGRD TVRWKITNNV QRPGFATHAA STSPTELVPY GLSLRLGRLC TENLMKPGTR 840
ECDQLRQEVE ENLNEVYRQV SGAHKLQQTK FRQQPNTGKK QDHTIVDTVL LAPRSAKQML 900
LKLTEKQVEQ GSFHELKVAP GYYTVTAEQD ARGMVEFQEG VELVDVRVPL FIRPEDDDEK 960
QLLVEAIDVP VGTATLGRRL VNITIIKEQA SGVVSFEQPE YSVSRGDQVA RIPVIRHILD 1020
NGKSQVSYST QDNTAHGHRD YVPVEGELLF HPGETWKELQ VKLLELQEVD SLLRGRQVRR 1080
FQVQLSNPKF GARLGQPSTT TVILGEHDET DRSLINQTLS SPPPPHGDLG APQNPNAKAA 1140
GSRKIHFNWL PPPGKPMGYR VKYWIQGDSE SEAHLLDSKV PSVELTNLYP YCDYEMKVCA 1200
YGAQGEGPYS SLVSCRTHQE VPSEPGRLAF NVVSSTVTQL SWAEPAETNG EITAYEVCYG 1260
LVNEDNRPIG PMKKVLVDNP KNRMLLIENL RESQPYRYTV KARNGAGWGP EREAIINLAT 1320
QPKRPMSIPI IPDIPIVDAQ GGEDYENFLM YSDDVLRSPA SSQRPSVSDD TGCGWKFEPL 1380
LGEELDLRRV TWRLPPELIP RLSASSGRSD EDGSVAGGVE GEGSGWIRGA TPRPPGEHLV 1440
NGRMDFAYPG SANSLHRMTA ANVAYGTHLS PHLSHRVLST SSTLTRDYHS LTRTEHSHSG 1500
TLPRDYSTLT SLSSQDSRGA VGVPDTPTRL VFSALGPTSL KVSWQEPQCD RMLLGYSVEY 1560
QLLNGGEMHR LNIPNPGQTS VVVEDLLPNH SYVFRVRAQS QEGWGREREG VITIESQVHP 1620
QSPLCPLPGS AFTLSTPSAP GPLVFTALSP DSLQLSWERP RRPNGDILGY LVTCEMAQGG 1680
APARTFRVDG DNPESRLTVP GLSENVPYKF KVQARTTEGF GPEREGIITI ESQVGGPFPQ 1740
LGSHSGLFQN PVQSEFSSVT STHSTTTEPF LMDGLTLGTQ RLEAGGSLTR HVTQEFVTRT 1800
LTASGSLSTH MDQQFFQT 1818 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |