UniProt Accession

 J3QN85_MOUSE; J3QN85 

Genbank Protein ID

 AC160526 

Genbank Nucleotide ID

  

Protein Name

 Fibroblast growth factor receptor 

Protein Synonyms/Alias

  

Gene Name

 Fgfr1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
209	LKNGKEFKPDHRIGG	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

 ACT_SITE 634 634 Proton acceptor (By similarity).  

Keyword

 ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 833 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005007; F:fibroblast growth factor-activated receptor activity; IDA:MGI.
 GO:0001525; P:angiogenesis; IGI:MGI.
 GO:0060117; P:auditory receptor cell development; IMP:MGI.
 GO:0060445; P:branching involved in salivary gland morphogenesis; IMP:MGI.
 GO:0048469; P:cell maturation; IMP:MGI.
 GO:0002062; P:chondrocyte differentiation; IGI:MGI.
 GO:0030326; P:embryonic limb morphogenesis; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IGI:MGI.
 GO:0042472; P:inner ear morphogenesis; IMP:MGI.
 GO:0060484; P:lung-associated mesenchyme development; IGI:MGI.
 GO:0048762; P:mesenchymal cell differentiation; IGI:MGI.
 GO:0030901; P:midbrain development; IMP:MGI.
 GO:0042474; P:middle ear morphogenesis; IMP:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.
 GO:0010629; P:negative regulation of gene expression; IMP:MGI.
 GO:0001759; P:organ induction; IMP:MGI.
 GO:0042473; P:outer ear morphogenesis; IMP:MGI.
 GO:0048339; P:paraxial mesoderm development; IGI:MGI.
 GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IGI:MGI.
 GO:0090080; P:positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway; IGI:MGI.
 GO:0002053; P:positive regulation of mesenchymal cell proliferation; IMP:MGI.
 GO:0010976; P:positive regulation of neuron projection development; IGI:MGI.
 GO:0060665; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; IDA:MGI.
 GO:0048378; P:regulation of lateral mesodermal cell fate specification; IGI:MGI.
 GO:0007605; P:sensory perception of sound; IMP:MGI.
 GO:0001657; P:ureteric bud development; IGI:MGI. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003598; Ig_sub2.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom.
 IPR016248; Tyr_kinase_fibroblast_GF_rcpt. 

Pfam

 PF07679; I-set
 PF07714; Pkinase_Tyr 

SMART

 SM00408; IGc2
 SM00219; TyrKc 

PROSITE

 PS50835; IG_LIKE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR 

PRINTS

 PR00109; TYRKINASE.