UniProt Accession

 JTB_HUMAN; O76095; O95442; Q6IB19; Q9P0Q4 

Genbank Protein ID

 AB016492; AB016488; AB016493; AF115850; AF131797; AF151056; BT007285; CR456985; AK312106; AL358472; AL358472; AL358472; CH471121; CH471121; CH471121; BC000499; BC000996; BC001363; BC001667; BC004239; BC019277 

Genbank Nucleotide ID

 BAA33735.1; BAA33731.1; BAA33736.1; AAD09822.2; AAD20045.1; AAF36142.1; AAP35949.1; CAG33266.1; BAG35042.1; CAI14028.1; CAI14029.1; CAI14030.1; EAW53241.1; EAW53242.1; EAW53244.1; AAH00499.1; AAH00996.1; AAH01363.1; AAH01667.1; AAH04239.1; AAH19277.1 

Protein Name

 Protein JTB 

Protein Synonyms/Alias

 Jumping translocation breakpoint protein; Prostate androgen-regulated protein; PAR protein 

Gene Name

 JTB 

Gene Synonyms/Alias

 HSPC222 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
69	PCSNFRAKTTPECGP	ubiquitination	[1, 2]
82	GPTGYVEKITCSSSK	ubiquitination	[2]
141	KALEKVRKQIESI**	ubiquitination	[2]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity). 

Sequence Annotation

  

Keyword

 3D-structure; Alternative splicing; Apoptosis; Cell cycle; Cell division; Complete proteome; Cytoplasm; Cytoskeleton; Membrane; Mitochondrion; Mitosis; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 146 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
 GO:0030496; C:midbody; IDA:UniProtKB.
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
 GO:0019901; F:protein kinase binding; IDA:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0000910; P:cytokinesis; IMP:UniProtKB.
 GO:0007067; P:mitosis; IMP:UniProtKB.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0045860; P:positive regulation of protein kinase activity; IMP:UniProtKB.
 GO:0042127; P:regulation of cell proliferation; IEA:Compara. 

Interpro

 IPR008657; JTB. 

Pfam

 PF05439; JTB 

SMART

  

PROSITE

  

PRINTS