CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026419
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein Ppp2r1a 
Protein Synonyms/Alias
 Protein phosphatase 2 (Formerly 2A), regulatory subunit A (PR 65), alpha isoform, isoform CRA_a; Protein phosphatase 2 (Formerly 2A), regulatory subunit A, alpha isoform 
Gene Name
 Ppp2r1a 
Gene Synonyms/Alias
 rCG_22961 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
133AHFVPLVKRLAGGDWacetylation[1]
163PRVSSAVKAELRQYFubiquitination[2]
188VRRAAASKLGEFAKVubiquitination[2]
266VRYMVADKFTELQKAacetylation[1]
266VRYMVADKFTELQKAubiquitination[2]
272DKFTELQKAVGPEITubiquitination[2]
280AVGPEITKTDLVPAFacetylation[1]
305VRAAASHKVKEFCENubiquitination[2]
472NLKKLVEKFGKEWAHacetylation[1]
561STLQSEVKPILEKLTacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 589 AA 
Protein Sequence
MAAADGDDSL YPIAVLIDEL RNEDVQLRLN SIKKLSTIAL ALGVERTRSE LLPFLTDTIY 60
DEDEVLLALA EQLGTFTTLV GGPEYVHCLL PPLESLATVE ETVVRDKAVE SLRAISHEHS 120
PSDLEAHFVP LVKRLAGGDW FTSRTSACGL FSVCYPRVSS AVKAELRQYF RNLCSDDTPM 180
VRRAAASKLG EFAKVLELDN VKSEIIPMFS NLASDEQDSV RLLAVEACVN IAQLLPQEDL 240
EALVMPTLRQ AAEDKSWRVR YMVADKFTEL QKAVGPEITK TDLVPAFQNL MKDCEAEVRA 300
AASHKVKEFC ENLSADCREN VIMTQILPCI KELVSDANQH VKSALASVIM GLSPILGKDN 360
TIEHLLPLFL AQLKDECPEV RLNIISNLDC VNEVIGIRQL SQSLLPAIVE LAEDAKWRVR 420
LAIIEYMPLL AGQLGVEFFD EKLNSLCMAW LVDHVYAIRE AATSNLKKLV EKFGKEWAHA 480
TIIPKVLAMS GDPNYLHRMT TLFCINVLSE VCGQDITTKH MLPTVLRMAG DPVANVRFNV 540
AKSLQKIGPI LDNSTLQSEV KPILEKLTQD QDVDVKYFAQ EALTVLSLA 589 
Gene Ontology
 GO:0000775; C:chromosome, centromeric region; IEA:Compara.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0000159; C:protein phosphatase type 2A complex; IEA:Compara.
 GO:0003823; F:antigen binding; IEA:Compara.
 GO:0004722; F:protein serine/threonine phosphatase activity; IEA:Compara.
 GO:0007059; P:chromosome segregation; IEA:Compara.
 GO:0070262; P:peptidyl-serine dephosphorylation; IEA:Compara.
 GO:0042981; P:regulation of apoptotic process; IEA:Compara. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR000357; HEAT.
 IPR021133; HEAT_type_2. 
Pfam
 PF02985; HEAT 
SMART
  
PROSITE
 PS50077; HEAT_REPEAT 
PRINTS