| Tag | Content |
|---|
| CPLM ID | CPLM-002298 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | HTH-type transcriptional regulator IlvY |
Protein Synonyms/Alias | |
Gene Name | ilvY |
Gene Synonyms/Alias | b3773; JW3746 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 7 | *MDLRDLKTFLHLAE | acetylation | [1] | | 185 | RNQVSVEKPDWSTVP | acetylation | [1] | | 267 | ILERSDEKTPFELGV | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression. |
Sequence Annotation | DOMAIN 1 58 HTH lysR-type.
DNA_BIND 18 37 H-T-H motif (By similarity). |
Keyword | Activator; Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; Cytoplasm; DNA-binding; Reference proteome; Repressor; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 297 AA |
Protein Sequence | MDLRDLKTFL HLAESRHFGR SARAMHVSPS TLSRQIQRLE EDLGQPLFVR DNRTVTLTEA 60
GEELRVFAQQ TLLQYQQLRH TIDQQGPSLS GELHIFCSVT AAYSHLPPIL DRFRAEHPSV 120
EIKLTTGDAA DAMEKVVTGE ADLAIAGKPE TLPGAVAFSM LENLAVVLIA PALPCPVRNQ 180
VSVEKPDWST VPFIMADQGP VRRRIELWFR RNKISNPMIY ATVGGHEAMV SMVALGCGVA 240
LLPEVVLENS PEPVRNRVMI LERSDEKTPF ELGVCAQKKR LHEPLIEAFW KILPNHK 297 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro. GO:0009082; P:branched-chain amino acid biosynthetic process; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |