UniProt Accession

 TMED3_HUMAN; Q9Y3Q3; A8K069; B4DN05; Q2T9F8 

Genbank Protein ID

 AJ132270; AL109672; AY358974; CR457384; AK289434; AK297710; AC011797; AC027811; BC000027; BC010853; BC017495; BC022232; BC111547 

Genbank Nucleotide ID

 CAB40416.1; CAB52017.1; AAQ89333.1; CAG33665.1; BAF82123.1; BAG60067.1; AAH00027.1; AAH10853.1; AAH17495.1; AAH22232.1; AAI11548.1 

Protein Name

 Transmembrane emp24 domain-containing protein 3 

Protein Synonyms/Alias

 Membrane protein p24B; p24 family protein gamma-4; p24gamma4; p26 

Gene Name

 TMED3 

Gene Synonyms/Alias

 C15orf22; UNQ5357/PRO1078 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
83	TIYRETKKQYDSFTY	ubiquitination	[1]
152	VTIHEALKTVIDSQT	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. 

Sequence Annotation

 DOMAIN 38 120 GOLD.
 MOTIF 204 217 COPI vesicle coat-binding (Potential).
 MOTIF 204 205 COPII vesicle coat-binding (Potential).  

Keyword

 Alternative splicing; Complete proteome; Cytoplasmic vesicle; Endoplasmic reticulum; Golgi apparatus; Membrane; Polymorphism; Protein transport; Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 217 AA 

Protein Sequence

Gene Ontology

 GO:0030126; C:COPI vesicle coat; ISS:UniProtKB.
 GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IDA:UniProtKB.
 GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
 GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR009038; GOLD.
 IPR015718; P24-related. 

Pfam

 PF01105; EMP24_GP25L 

SMART

  

PROSITE

 PS50866; GOLD 

PRINTS