CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017339
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine/threonine-protein kinase 11-interacting protein 
Protein Synonyms/Alias
 LKB1-interacting protein 1 
Gene Name
 STK11IP 
Gene Synonyms/Alias
 KIAA1898; LIP1; LKB1IP; STK11IP1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
114PGPTGPIKIFPFKSLubiquitination[1, 2]
294WLLAELRKLYLEGNPubiquitination[1, 2, 3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 May regulate STK11/LKB1 function by controlling its subcellular localization. 
Sequence Annotation
 REPEAT 120 141 LRR 1.
 REPEAT 143 163 LRR 2.
 REPEAT 175 196 LRR 3.
 REPEAT 198 220 LRR 4.
 REPEAT 221 242 LRR 5.
 REPEAT 244 265 LRR 6.
 REPEAT 266 287 LRR 7.
 REPEAT 291 312 LRR 8.
 MOD_RES 398 398 Phosphoserine.
 MOD_RES 400 400 Phosphoserine.
 MOD_RES 403 403 Phosphoserine.
 MOD_RES 772 772 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Leucine-rich repeat; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1099 AA 
Protein Sequence
MFGSAPQRPV AMTTAQRDSL LWKLAGLLRE SGDVVLSGCS TLSLLTPTLQ QLNHVFELHL 60
GPWGPGQTGF VALPSHPADS PVILQLQFLF DVLQKTLSLK LVHVAGPGPT GPIKIFPFKS 120
LRHLELRGVP LHCLHGLRGI YSQLETLICS RSLQALEELL SACGGDFCSA LPWLALLSAN 180
FSYNALTALD SSLRLLSALR FLNLSHNQVQ DCQGFLMDLC ELHHLDISYN RLHLVPRMGP 240
SGAALGVLIL RGNELRSLHG LEQLRNLRHL DLAYNLLEGH RELSPLWLLA ELRKLYLEGN 300
PLWFHPEHRA ATAQYLSPRA RDAATGFLLD GKVLSLTDFQ THTSLGLSPM GPPLPWPVGS 360
TPETSGGPDL SDSLSSGGVV TQPLLHKVKS RVRVRRASIS EPSDTDPEPR TLNPSPAGWF 420
VQQHPELELM SSFRERFGRN WLQYRSHLEP SGNPLPATPT TSAPSAPPAS SQGPDTAPRP 480
SPPQEEARGP QESPQKMSEE VRAEPQEEEE EKEGKEEKEE GEMVEQGEEE AGEEEEEEQD 540
QKEVEAELCR PLLVCPLEGP EGVRGRECFL RVTSAHLFEV ELQAARTLER LELQSLEAAE 600
IEPEAQAQRS PRPTGSDLLP GAPILSLRFS YICPDRQLRR YLVLEPDAHA AVQELLAVLT 660
PVTNVAREQL GEARDLLLGR FQCLRCGHEF KPEEPRMGLD SEEGWRPLFQ KTESPAVCPN 720
CGSDHVVLLA VSRGTPNRER KQGEQSLAPS PSASPVCHPP GHGDHLDRAK NSPPQAPSTR 780
DHGSWSLSPP PERCGLRSVD HRLRLFLDVE VFSDAQEEFQ CCLKVPVALA GHTGEFMCLV 840
VVSDRRLYLL KVTGEMREPP ASWLQLTLAV PLQDLSGIEL GLAGQSLRLE WAAGAGRCVL 900
LPRDARHCRA FLEELLDVLQ SLPPAWRNCV SATEEEVTPQ HRLWPLLEKD SSLEARQFFY 960
LRAFLVEGPS TCLVSLLLTP STLFLLDEDA AGSPAEPSPP AASGEASEKV PPSGPGPAVR 1020
VREQQPLSSL SSVLLYRSAP EDLRLLFYDE VSRLESFWAL RVVCQEQLTA LLAWIREPWE 1080
ELFSIGLRTV IQEALALDR 1099 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0008104; P:protein localization; IDA:UniProtKB. 
Interpro
 IPR001611; Leu-rich_rpt. 
Pfam
  
SMART
  
PROSITE
 PS51450; LRR 
PRINTS