| Tag | Content |
|---|
| CPLM ID | CPLM-018167 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Phosphopantothenate--cysteine ligase |
Protein Synonyms/Alias | Phosphopantothenoylcysteine synthetase; PPC synthetase |
Gene Name | Ppcs |
Gene Synonyms/Alias | Coab |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 46 | LITSGGTKVPLEARA | ubiquitination | [1] | | 208 | GPLQITMKMVPKMLS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine (By similarity). |
Sequence Annotation | |
Keyword | Alternative splicing; Complete proteome; Ligase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 311 AA |
Protein Sequence | MAEMDLVAEL PRPAGAARWA EVMARFAARL GEQGRRVVLI TSGGTKVPLE ARAVRFLDNF 60
SSGRRGAASA EVFLAAGYGV LFLYRARSAF PYAHRFPPQA WLSALRPSGP AQSGKLSLEA 120
EENALPGFAA ALQSYQEAAA AGTFLAVEFT TLADYLHLLQ AAALALSPLG SSAMFYLAAA 180
VSDFYIPVSE MPEHKIHSSG GPLQITMKMV PKMLSPLVKD WAPKAFVVSF KLETDPDIII 240
SRARNALEVY QHQVVVANIL ESIKSFVIIV TKDSETELLL SEEEVAKGLV IEEKIVDDLR 300
SRHTAFICDK N 311 |
Gene Ontology | GO:0004632; F:phosphopantothenate--cysteine ligase activity; IEA:EC. GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |