CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006437
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein SPT23 
Protein Synonyms/Alias
  
Gene Name
 SPT23 
Gene Synonyms/Alias
 YKL020C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
486TFSRLPQKFIDSSKDacetylation[1]
486TFSRLPQKFIDSSKDubiquitination[2]
637VGLKMNGKLEDARNIubiquitination[2]
811DILTRLTKNTTGSSDubiquitination[2]
909KIKDFSSKPNEIPKTubiquitination[2]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Dosage-dependent suppressor of Ty-induced promoter mutations. May exert its suppression effect through protein- protein interactions since does not present any of the motifs generally found in transcriptional activators or DNA binding proteins. 
Sequence Annotation
 DOMAIN 508 585 IPT/TIG.
 REPEAT 709 738 ANK 1.
 REPEAT 742 771 ANK 2.
 MOD_RES 468 468 Phosphoserine.  
Keyword
 ANK repeat; Complete proteome; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1082 AA 
Protein Sequence
MMSGTGNVSS MLHSYSANIQ HNDGSPDLDL LESELLDIAL LNSGSSLQDP GLLSLNQEKM 60
ITAGTTTPGK EDEGELRDDI ASLQGLLDRH VQFGRKLPLR TPYANPLDFI NINPQSLPLS 120
LEIIGLPKVS RVETQMKLSF RIRNAHARKN FFIHLPSDCI AKDKFFTSSD DPTNLTIPNR 180
DINERTLFLD AFLLCASNNN SNNFKQTYVC NRCINREKRR ASRRKSGLND NSIWQNNENK 240
RAIIFNSKQL FIISNNGLSG NSNCINFDLP TRIVCYCRHH KATNGFVVLF LLRDHNGDIL 300
AKTITDPIMI MDKKNASNTT TPTSTSNAQV SPMTNDTRSF SSPQSDLNFP SEFPLPSNSK 360
NFVISTNCML DSNCNNNNND NDNKNNIKTN TAMMNNNRHF PSPNSSSEDS NHSFSDIHFS 420
NNNDNNLHRS LDSWSSTGFN SSSNPALTTL TSDFSAASAR HTGKRQRSVN EPFMSTPNTF 480
SRLPQKFIDS SKDISNHNSV PVALNNKPSI QRVIPAQGSI NGGIEVTLLG SKFKQGLIIK 540
FGENIALSSQ CWNESTMVTY LPPSSKPGPV LVTIVDPSET SMRNNSNSSV STSNSTNDIL 600
HLNKYTGEKA IFTYVDDTDR QLIELALQIV GLKMNGKLED ARNIAKRIVG SDSSPSNNNA 660
GLHSQNSSLN SYTNMMRNIN DEQLITEVIK SFKRNNNLST VNLSMCDVRG RTLLHLAAFN 720
NWYSLVSLLI KYGSHLNDQD LFGFTPLHMA CINGDLRIIR LLLECNVNIM KKTRNGFIAK 780
QFFLMNYTVN KTRYSNYETS LFDDILTRLT KNTTGSSDTQ PFERNVSQSS FNSSLFDDDD 840
ADHDYVQERK YLLADSAALA PEQSNCNDNT SFSILDSDSG YDISDCESSS DEIALEFFNT 900
HKIKDFSSKP NEIPKTTKTS IEPDGSLWNR MLTRLNDELP KYEDLFPKKP KNWELGSKSV 960
EIGPDNSAQM TVDDSQTSSE DDELEALQVG FNTIFSKKQN FQNDKMLLFF WIPLTLVLLL 1020
CFTLSNLGKD DDMFHNLSKI VQEYLRIGLA KVLLGNERMK TSFKMQLSKF QNNNILNDMR 1080
VN 1082 
Gene Ontology
 GO:0030176; C:integral to endoplasmic reticulum membrane; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0003677; F:DNA binding; IPI:SGD.
 GO:0070417; P:cellular response to cold; IGI:SGD.
 GO:0030466; P:chromatin silencing at silent mating-type cassette; IGI:SGD.
 GO:0036083; P:positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter; IGI:SGD. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR013783; Ig-like_fold.
 IPR014756; Ig_E-set.
 IPR002909; IPT_TIG_rcpt. 
Pfam
 PF00023; Ank
 PF01833; TIG 
SMART
 SM00248; ANK
 SM00429; IPT 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT 
PRINTS