CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015300
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein SHQ1 homolog 
Protein Synonyms/Alias
  
Gene Name
 SHQ1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
43SDFKFYAKPYFLRLTubiquitination[1, 2, 3]
69QGSYDADKGIFTIRLubiquitination[4]
172LSDVIDIKDPDFTPAubiquitination[2, 4]
222YNPWWTDKYSKMMAFubiquitination[1, 2, 3]
259QLRKFVNKSYLLDKRubiquitination[2]
265NKSYLLDKRACRQVCubiquitination[2]
293TRVTEGEKNVESAWNubiquitination[2, 4]
406AALAEALKEVSLTKAubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA. 
Sequence Annotation
 DOMAIN 1 89 CS.  
Keyword
 Complete proteome; Cytoplasm; Nucleus; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 577 AA 
Protein Sequence
MLTPAFDLSQ DPDFLTIAIR VPYARVSEFD VYFEGSDFKF YAKPYFLRLT LPGRIVENGS 60
EQGSYDADKG IFTIRLPKET PGQHFEGLNM LTALLAPRKS RTAKPLVEEI GASEIPEEVV 120
DDEEFDWEIE QTPCEEVSES ALNPQCHYGF GNLRSGVLQR LQDELSDVID IKDPDFTPAA 180
ERRQKRLAAE LAKFDPDHYL ADFFEDEAIE QILKYNPWWT DKYSKMMAFL EKSQEQENHA 240
TLVSFSEEEK YQLRKFVNKS YLLDKRACRQ VCYSLIDILL AYCYETRVTE GEKNVESAWN 300
IRKLSPTLCW FETWTNVHDI MVSFGRRVLC YPLYRHFKLV MKAYRDTIKI LQLGKSAVLK 360
CLLDIHKIFQ ENDPAYILND LYISDYCVWI QKVKSKKLAA LAEALKEVSL TKAQLGLELE 420
ELEAAALLVQ EEETALKAAH SVSGQQTLCS SSEASDSEDS DSSVSSGNED SGSDSEQDEL 480
KDSPSETVSS LQGPFLEESS AFLIVDGGVR RNTAIQESDA SQGKPLASSW PLGVSGPLIE 540
ELGEQLKTTV QVSEPKGTTA VNRSNIQERD GCQTPNN 577 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0005654; C:nucleoplasm; IDA:UniProtKB.
 GO:2000233; P:negative regulation of rRNA processing; IDA:MGI.
 GO:0043065; P:positive regulation of apoptotic process; IDA:MGI.
 GO:0022618; P:ribonucleoprotein complex assembly; IDA:UniProtKB. 
Interpro
 IPR007052; CS-like_domain.
 IPR008978; HSP20-like_chaperone.
 IPR007009; SHQ1. 
Pfam
 PF04925; SHQ1 
SMART
  
PROSITE
 PS51203; CS 
PRINTS