UniProt Accession

 RPC6_HUMAN; Q9H1D9; A8K4C7; O15319 

Genbank Protein ID

 U93869; AK290892; AL121893; CH471133; BC012588 

Genbank Nucleotide ID

 AAB63677.1; BAF83581.1; CAC11110.1; EAX10240.1; AAH12588.1 

Protein Name

 DNA-directed RNA polymerase III subunit RPC6 

Protein Synonyms/Alias

 RNA polymerase III subunit C6; DNA-directed RNA polymerase III subunit F; RNA polymerase III 39 kDa subunit; RPC39 

Gene Name

 POLR3F 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
256	EMTIIAAKEGTVGSV	ubiquitination	[1]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. 

Sequence Annotation

  

Keyword

 3D-structure; Antiviral defense; Complete proteome; DNA-directed RNA polymerase; Immunity; Innate immunity; Nucleus; Reference proteome; Transcription. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 316 AA 

Protein Sequence

Gene Ontology

 GO:0005666; C:DNA-directed RNA polymerase III complex; NAS:UniProtKB.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0003899; F:DNA-directed RNA polymerase activity; NAS:UniProtKB.
 GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
 GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
 GO:0045089; P:positive regulation of innate immune response; IMP:UniProtKB.
 GO:0032728; P:positive regulation of interferon-beta production; IMP:UniProtKB.
 GO:0006359; P:regulation of transcription from RNA polymerase III promoter; NAS:UniProtKB.
 GO:0006386; P:termination of RNA polymerase III transcription; TAS:Reactome.
 GO:0006385; P:transcription elongation from RNA polymerase III promoter; TAS:Reactome. 

Interpro

 IPR007832; RNA_pol_Rpc34.
 IPR016049; RNA_pol_Rpc34-like. 

Pfam

 PF05158; RNA_pol_Rpc34 

SMART

  

PROSITE

  

PRINTS