UniProt Accession

 PYRE_THET8; Q5SHI8 

Genbank Protein ID

 AP008226 

Genbank Nucleotide ID

 BAD71565.1 

Protein Name

 Orotate phosphoribosyltransferase 

Protein Synonyms/Alias

 OPRT; OPRTase 

Gene Name

 pyrE 

Gene Synonyms/Alias

 TTHA1742 

Created Date

 July 27, 2013 

Organism

 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) 

NCBI Taxa ID

 300852 

Lysine Modification

Position	Peptide	Type	References
88	ARALFAEKDGRGGML	acetylation	[1]

Reference

 [1] Acetylome with structural mapping reveals the significance of lysine acetylation in Thermus thermophilus.
 Okanishi H, Kim K, Masui R, Kuramitsu S.
 J Proteome Res. 2013 Aug 1;. [PMID: 23901841] 

Functional Description

 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity). 

Sequence Annotation

 REGION 112 120 5-phosphoribose 1-diphosphate binding (By
 BINDING 21 21 5-phosphoribose 1-diphosphate (By
 BINDING 88 88 5-phosphoribose 1-diphosphate (By
 BINDING 116 116 Orotate (By similarity).
 BINDING 144 144 Orotate (By similarity).  

Keyword

 Complete proteome; Glycosyltransferase; Magnesium; Pyrimidine biosynthesis; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 183 AA 

Protein Sequence

Gene Ontology

 GO:0000287; F:magnesium ion binding; IEA:HAMAP.
 GO:0004588; F:orotate phosphoribosyltransferase activity; IEA:HAMAP.
 GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0019856; P:pyrimidine nucleobase biosynthetic process; IEA:InterPro. 

Interpro

 IPR023031; OPRT.
 IPR006273; Orotate_PRibTrfase_bac.
 IPR000836; PRibTrfase_dom. 

Pfam

 PF00156; Pribosyltran 

SMART

  

PROSITE

 PS00103; PUR_PYR_PR_TRANSFER 

PRINTS