UniProt Accession

 THTPA_RAT; Q8CGV7 

Genbank Protein ID

 BC081978; AY065967 

Genbank Nucleotide ID

 AAH81978.1; AAL41027.1 

Protein Name

 Thiamine-triphosphatase 

Protein Synonyms/Alias

 ThTPase 

Gene Name

 Thtpa 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
193	AQEKAPAKLLVYLQR	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Hydrolase highly specific for thiamine triphosphate (ThTP) (By similarity). 

Sequence Annotation

 METAL 7 7 Magnesium (By similarity).
 METAL 9 9 Magnesium (By similarity).
 METAL 145 145 Magnesium (By similarity).
 METAL 157 157 Magnesium (By similarity).
 METAL 159 159 Magnesium (By similarity).
 BINDING 11 11 Substrate (By similarity).
 BINDING 55 55 Substrate (By similarity).
 BINDING 57 57 Substrate (By similarity).
 BINDING 65 65 Substrate (By similarity).
 BINDING 125 125 Substrate (By similarity).
 BINDING 193 193 Substrate (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Hydrolase; Magnesium; Metal-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 224 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0050333; F:thiamin-triphosphatase activity; ISS:UniProtKB.
 GO:0016311; P:dephosphorylation; IEA:Compara.
 GO:0006772; P:thiamine metabolic process; IEA:InterPro. 

Interpro

 IPR023577; CYTH-like_domain.
 IPR012177; ThTPase. 

Pfam

 PF01928; CYTH 

SMART

  

PROSITE

  

PRINTS