CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032223
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Forkhead box protein P4 
Protein Synonyms/Alias
  
Gene Name
 FOXP4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
165LTQQQAGKPQPKEALubiquitination[1]
175PKEALGNKQLAFQQQubiquitination[1, 2]
433ARRRSSDKFCSPISSubiquitination[1]
520FVRVENVKGAVWTVDubiquitination[1, 2, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; DNA-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 668 AA 
Protein Sequence
MMVESASETI RSAPSGQNGV GSLSGQADGS SGGATGTTAS GTGREVTTGA DSNGEMSPAE 60
LLHFQQQQAL QVARQFLLQQ ASGLSSPGNN DSKQSASAVQ VPVSVAMMSP QMLTPQQMQQ 120
ILSPPQLQAL LQQQQALMLQ QLQEYYKKQQ EQLHLQLLTQ QQAGKPQPKE ALGNKQLAFQ 180
QQLLQMQQLQ QQHLLNLQRQ GLVSLQPNQA SGPLQTLPQA AVCPTDLPQL WKGEGAPGQP 240
AEDSVKQEGL DLTGTAATAT SFAAPPKVSP PLSHHTLPNG QPTVLTSRRD SSSHEETPGS 300
HPLYGHGECK WPGCETLCED LGQFIKHLNT EHALDDRSTA QCRVQMQVVQ QLEIQLAKES 360
ERLQAMMAHL HMRPSEPKPF SQPVTVSAAD SFPDGLVHPP TSAAAPVTPL RPPGLGSASL 420
HGGGPARRRS SDKFCSPISS ELAQNHEFYK NADVRPPFTY ASLIRQAILE TPDRQLTLNE 480
IYNWFTRMFA YFRRNTATWK NAVRHNLSLH KCFVRVENVK GAVWTVDERE YQKRRPPKMT 540
GSPTLVKNMI SGLSYGALNA SYQAALAESS FPLLNSPGML NPGSASSLLP LSHDDVGAPV 600
EPLPSNGSSS PPRLSPPQYS HQVQVKEEPA EAEEDRQPGP PLGAPNPSAS GPPEDRDLEE 660
ELPGEELS 668 
Gene Ontology
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro. 
Interpro
 IPR001766; TF_fork_head.
 IPR018122; TF_fork_head_CS.
 IPR011991; WHTH_DNA-bd_dom.
 IPR015880; Znf_C2H2-like. 
Pfam
 PF00250; Fork_head 
SMART
 SM00339; FH
 SM00355; ZnF_C2H2 
PROSITE
 PS00658; FORK_HEAD_2
 PS50039; FORK_HEAD_3 
PRINTS
 PR00053; FORKHEAD.