UniProt Accession

 ISCA1_HUMAN; Q9BUE6; B3KP34; Q8ND75; Q9BZR2 

Genbank Protein ID

 AY015642; AF284752; AK055643; AL834356; AL137849; BC002675; BC071621 

Genbank Nucleotide ID

 AAG40950.1; AAG59854.1; BAG51546.1; CAD39021.1; CAI14925.1; AAH02675.1; AAH71621.1 

Protein Name

 Iron-sulfur cluster assembly 1 homolog, mitochondrial 

Protein Synonyms/Alias

 HESB-like domain-containing protein 2; Iron-sulfur assembly protein IscA; hIscA 

Gene Name

 ISCA1 

Gene Synonyms/Alias

 HBLD2; GK004 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
89	VRVFIEKKAQLTLLG	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Involved in the assembly of mitochondrial iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly. 

Sequence Annotation

  

Keyword

 Complete proteome; Iron; Iron-sulfur; Metal-binding; Mitochondrion; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 129 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0016226; P:iron-sulfur cluster assembly; IEA:InterPro. 

Interpro

 IPR000361; FeS_biogenesis.
 IPR016092; FeS_cluster_insertion.
 IPR017870; FeS_cluster_insertion_CS. 

Pfam

 PF01521; Fe-S_biosyn 

SMART

  

PROSITE

 PS01152; HESB 

PRINTS