UniProt Accession

 PEX14_HUMAN; O75381; B2R7N1; B3KML6; B7Z1N2; Q8WX51 

Genbank Protein ID

 AF045186; AB017546; AK002194; AK293684; AK313046; CR450321; CR542083; AL139423; AL354956; AL591403; AL354956; AL139423; AL591403; AL591403; AL139423; AL354956; CH471130; BC006327 

Genbank Nucleotide ID

 AAC39843.1; BAA36837.1; BAG51028.1; BAH11568.1; BAG35878.1; CAG29317.1; CAG46880.1; CAD20149.2; CAD20149.2; CAD20149.2; CAI19198.1; CAI19198.1; CAI19198.1; CAH70044.1; CAH70044.1; CAH70044.1; EAW71661.1; AAH06327.1 

Protein Name

 Peroxisomal membrane protein PEX14 

Protein Synonyms/Alias

 PTS1 receptor-docking protein; Peroxin-14; Peroxisomal membrane anchor protein PEX14 

Gene Name

 PEX14 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
170	SQNINELKSEINSLK	ubiquitination	[1]
177	KSEINSLKGLLLNRR	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Component of the peroxisomal translocation machinery with PEX13 and PEX17. Interacts with both the PTS1 and PTS2 receptors. Binds directly to PEX17. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 34 34 N6-acetyllysine.
 MOD_RES 335 335 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Membrane; Peroxisome; Peroxisome biogenesis disorder; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Translocation; Transport; Zellweger syndrome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 377 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; ISS:UniProtKB.
 GO:0005634; C:nucleus; NAS:UniProtKB.
 GO:0005778; C:peroxisomal membrane; IDA:UniProtKB.
 GO:0043234; C:protein complex; IDA:UniProtKB.
 GO:0008017; F:microtubule binding; IDA:UniProtKB.
 GO:0003714; F:transcription corepressor activity; IDA:UniProtKB.
 GO:0034453; P:microtubule anchoring; IDA:UniProtKB.
 GO:0032091; P:negative regulation of protein binding; IDA:UniProtKB.
 GO:1901094; P:negative regulation of protein homotetramerization; IDA:UniProtKB.
 GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0036250; P:peroxisome transport along microtubule; IDA:UniProtKB.
 GO:0051260; P:protein homooligomerization; IDA:UniProtKB.
 GO:0044721; P:protein import into peroxisome matrix, substrate release; IDA:UniProtKB.
 GO:0016561; P:protein import into peroxisome matrix, translocation; IDA:UniProtKB. 

Interpro

 IPR025655; PEX14.
 IPR006785; Pex14_N. 

Pfam

 PF04695; Pex14_N 

SMART

  

PROSITE

  

PRINTS