CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018934
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP synthase subunit b, mitochondrial 
Protein Synonyms/Alias
 ATPase subunit b; FO-ATP synthase subunit b 
Gene Name
 ATPsyn-b 
Gene Synonyms/Alias
 ATPsyn-beta; CG8189 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
144SDAIEAEKKEQWRADacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702
Functional Description
 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. 
Sequence Annotation
  
Keyword
 Alternative splicing; CF(0); Complete proteome; Hydrogen ion transport; Ion transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Transit peptide; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 243 AA 
Protein Sequence
MFSRAALLTA QRPLTVAATR SAAAAAAPGG AIERRQRPEH PGKVRLGFLP EEWFQFFYNK 60
TGVTGPYTFG VGLITYLCSK EIYVMEHEYY SGLSLGIMAI IAVKKLGPVI AKWADGEIDK 120
IESEWKEGRE AELKVLSDAI EAEKKEQWRA DGALLLMEAK KENIALQLEA AFRERAMNVY 180
SEVKRRLDYQ VECRHVERRL SQKHMVNWIT TNVLASISPQ QEKETLNKCI ADLSALALRV 240
KSA 243 
Gene Ontology
 GO:0005811; C:lipid particle; IDA:FlyBase.
 GO:0000276; C:mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); IBA:RefGenome.
 GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IBA:RefGenome.
 GO:0015986; P:ATP synthesis coupled proton transport; IBA:RefGenome.
 GO:0006911; P:phagocytosis, engulfment; IMP:FlyBase. 
Interpro
 IPR008688; ATPase_B_chain/sub_B/MI25.
 IPR013837; ATPase_F0_sub_B/B_chain. 
Pfam
 PF05405; Mt_ATP-synt_B 
SMART
  
PROSITE
  
PRINTS