CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022615
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 F-box-like/WD repeat-containing protein TBL1X 
Protein Synonyms/Alias
 Transducin beta-like protein 1X 
Gene Name
 Tbl1x 
Gene Synonyms/Alias
 Tbl1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
290FALKWNKKGNYILSAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity). 
Sequence Annotation
 DOMAIN 4 36 LisH.
 DOMAIN 41 86 F-box-like.
 REPEAT 180 219 WD 1.
 REPEAT 236 275 WD 2.
 REPEAT 277 316 WD 3.
 REPEAT 319 359 WD 4.
 REPEAT 360 399 WD 5.
 REPEAT 402 450 WD 6.
 REPEAT 453 492 WD 7.
 REPEAT 494 526 WD 8.  
Keyword
 Activator; Complete proteome; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Ubl conjugation pathway; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 527 AA 
Protein Sequence
MSITSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GTLVPPAALI SILQKGLQYV 60
EAEISINEDG TVFDGRPIES LSLIDAVMPD VVQTRQQAFR EKLAQQQANA AAAAAAAAAT 120
ATSTAATTPA AAAQQNPPKN GEATVNGEEN GAHAINNHSK PMEIDGDVEI PPSKATVLRG 180
HESEVFICAW NPVSDLLASG SGDSTARIWN LNENSNGGST QLVLRHCIRE GGHDVPSNKD 240
VTSLDWNSDG TLLATGSYDG FARIWTEDGN LASTLGQHKG PIFALKWNKK GNYILSAGVD 300
KTTIIWDAHT GEAKQQFPFH SAPALDVDWQ NNTTFASCST DMCIHVCRLG CDRPVKTFQG 360
HTNEVNAIKW DPSGMLLASC SDDMTLKIWS MKQDACVHDL QAHSKEIYTI KWSPTGPATS 420
NPNSNIMLAS ASFDSTVRLW DVERGVCIHT LTKHQEPVYS VAFSPDGKYL ASGSFDKCVH 480
IWNTQSGSLV HSYRGTGGIF EVCWNARGDK VGASASDGSV CVLDLRK 527 
Gene Ontology
 GO:0000118; C:histone deacetylase complex; IEA:Compara.
 GO:0005876; C:spindle microtubule; IEA:Compara.
 GO:0005667; C:transcription factor complex; IDA:MGI.
 GO:0017053; C:transcriptional repressor complex; IEA:Compara.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0003714; F:transcription corepressor activity; IMP:MGI.
 GO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0045444; P:fat cell differentiation; IMP:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IMP:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.
 GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IMP:MGI.
 GO:0043627; P:response to estrogen stimulus; IMP:MGI.
 GO:0007605; P:sensory perception of sound; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR020472; G-protein_beta_WD-40_rep.
 IPR006594; LisH_dimerisation.
 IPR013720; LisH_dimerisation_subgr.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF08513; LisH
 PF00400; WD40 
SMART
 SM00667; LisH
 SM00320; WD40 
PROSITE
 PS50896; LISH
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00320; GPROTEINBRPT.