CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005787
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Chitin synthase 3 
Protein Synonyms/Alias
 Chitin-UDP acetyl-glucosaminyl transferase 3; Class-IV chitin synthase 3 
Gene Name
 CHS3 
Gene Synonyms/Alias
 CAL1; CSD2; DIT101; KIT2; YBR023C; YBR0305 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
118QDMNTTDKKASVKISubiquitination[1]
136VAEDEFDKDGDVDNFubiquitination[1, 2, 3, 4]
496VDNKTMDKHTNDIEDubiquitination[1]
586MTTQNAWKLSNENKAubiquitination[1]
592WKLSNENKAVHSRNPubiquitination[1]
780PAEQGAAKPGNRGKRubiquitination[1]
1157REDILNRKEESDSFVubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] A proteomics approach to understanding protein ubiquitination.
 Peng J, Schwartz D, Elias JE, Thoreen CC, Cheng D, Marsischky G, Roelofs J, Finley D, Gygi SP.
 Nat Biotechnol. 2003 Aug;21(8):921-6. [PMID: 12872131]
 [3] Computational identification of ubiquitylation sites from protein sequences.
 Tung CW, Ho SY.
 BMC Bioinformatics. 2008 Jul 15;9:310. [PMID: 18625080]
 [4] Identification, analysis, and prediction of protein ubiquitination sites.
 Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM.
 Proteins. 2010 Feb 1;78(2):365-80. [PMID: 19722269] 
Functional Description
 Appears to be responsible for the synthesis of the majority of the chitin found in the cell wall periphery. It is involved in the synthesis of the chitin ring that forms in the cell wall just before bud emergence. This ring remains at the base of the bud as the bud grows and ultimately forms part of the bud scar marking the division site on the mother cell. 
Sequence Annotation
 MOD_RES 606 606 Phosphoserine.
 CROSSLNK 136 136 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Cell wall biogenesis/degradation; Complete proteome; Glycosyltransferase; Isopeptide bond; Membrane; Phosphoprotein; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1165 AA 
Protein Sequence
MTGLNGDDPD DYYLNLNQDE ESLLRSRHSV GSGAPHRQGS LVRPERSRLN NPDNPHFYYA 60
QKTQEQMNHL DVLPSSTGVN PNATRRSGSL RSKGSVRSKF SGRETDSYLL QDMNTTDKKA 120
SVKISDEGVA EDEFDKDGDV DNFEESSTQP INKSIKPLRK ETNDTLSFWQ MYCYFITFWA 180
PAPILAFCGM PKKERQMAWR EKVALISVIL YIGAIVAFLT FGFTKTVCSS SKLRLKNNEV 240
STEFVVINGK AYELDTSSRS GIQDVEVDSD TLYGPWSDAG KDASFLFQNV NGNCHNLITP 300
KSNSSIPHDD DNNLAWYFPC KLKNQDGSSK PNFTVENYAG WNCHTSKEDR DAFYGLKSKA 360
DVYFTWDGIK NSSRNLIVYN GDVLDLDLLD WLEKDDVDYP VVFDDLKTSN LQGYDLSLVL 420
SNGHERKIAR CLSEIIKVGE VDSKTVGCIA SDVVLYVSLV FILSVVIIKF IIACYFRWTV 480
ARKQGAYIVD NKTMDKHTND IEDWSNNIQT KAPLKEVDPH LRPKKYSKKS LGHKRASTFD 540
LLKKHSSKMF QFNESVIDLD TSMSSSLQSS GSYRGMTTMT TQNAWKLSNE NKAVHSRNPS 600
TLLPTSSMFW NKATSSPVPG SSLIQSLDST IIHPDIVQQP PLDFMPYGFP LIHTICFVTC 660
YSEDEEGLRT TLDSLSTTDY PNSHKLLMVV CDGLIKGSGN DKTTPEIALG MMDDFVTPPD 720
EVKPYSYVAV ASGSKRHNMA KIYAGFYKYD DSTIPPENQQ RVPIITIVKC GTPAEQGAAK 780
PGNRGKRDSQ IILMSFLEKI TFDERMTQLE FQLLKNIWQI TGLMADFYET VLMVDADTKV 840
FPDALTHMVA EMVKDPLIMG LCGETKIANK AQSWVTAIQV FEYYISHHQA KAFESVFGSV 900
TCLPGCFSMY RIKSPKGSDG YWVPVLANPD IVERYSDNVT NTLHKKNLLL LGEDRFLSSL 960
MLKTFPKRKQ VFVPKAACKT IAPDKFKVLL SQRRRWINST VHNLFELVLI RDLCGTFCFS 1020
MQFVIGIELI GTMVLPLAIC FTIYVIIFAI VSKPTPVITL VLLAIILGLP GLIVVITATR 1080
WSYLWWMCVY ICALPIWNFV LPSYAYWKFD DFSWGDTRTI AGGNKKAQDE NEGEFDHSKI 1140
KMRTWREFER EDILNRKEES DSFVA 1165 
Gene Ontology
 GO:0005935; C:cellular bud neck; IDA:SGD.
 GO:0045009; C:chitosome; IDA:SGD.
 GO:0000131; C:incipient cellular bud site; IDA:SGD.
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0043332; C:mating projection tip; IDA:SGD.
 GO:0005628; C:prospore membrane; IDA:SGD.
 GO:0004100; F:chitin synthase activity; IMP:SGD.
 GO:0030476; P:ascospore wall assembly; IMP:SGD.
 GO:0000910; P:cytokinesis; TAS:SGD.
 GO:0034221; P:fungal-type cell wall chitin biosynthetic process; TAS:SGD. 
Interpro
 IPR004835; Chitin_synth_fng. 
Pfam
 PF03142; Chitin_synth_2 
SMART
  
PROSITE
  
PRINTS