CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006969
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 TorCAD operon transcriptional regulatory protein TorR 
Protein Synonyms/Alias
  
Gene Name
 torR 
Gene Synonyms/Alias
 b0995; JW0980 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
102GADDYVTKPLELRELacetylation[1]
157ERDGEPIKLTRAEYEacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618
Functional Description
 Member of the two-component regulatory system TorS/TorR involved in the anaerobic utilization of trimethylamine-N-oxide (TMAO). Phosphorylated TorR activates the transcription of the torCAD operon by binding to four decameric boxes located in the torCAD promoter. Box1, 2 and 4 contain the DNA sequence 5'- CTGTTCATAT-3' and box3 contains the DNA sequence 5'-CCGTTCATCC-3'. Phosphorylated as well as unphosphorylated TorR negatively regulates its own expression by binding to box1 and 2. 
Sequence Annotation
 DOMAIN 1 117 Response regulatory.
 MOD_RES 53 53 4-aspartylphosphate (Probable).  
Keyword
 3D-structure; Activator; Complete proteome; Cytoplasm; Direct protein sequencing; DNA-binding; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Two-component regulatory system. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 230 AA 
Protein Sequence
MPHHIVIVED EPVTQARLQS YFTQEGYTVS VTASGAGLRE IMQNQSVDLI LLDINLPDEN 60
GLMLTRALRE RSTVGIILVT GRSDRIDRIV GLEMGADDYV TKPLELRELV VRVKNLLWRI 120
DLARQAQPHT QDNCYRFAGY CLNVSRHTLE RDGEPIKLTR AEYEMLVAFV TNPGEILSRE 180
RLLRMLSARR VENPDLRTVD VLIRRLRHKL SADLLVTQHG EGYFLAADVC 230 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0000156; F:phosphorelay response regulator activity; IDA:EcoCyc.
 GO:0006355; P:regulation of transcription, DNA-dependent; IDA:EcoCyc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR011006; CheY-like_superfamily.
 IPR001867; Sig_transdc_resp-reg_C.
 IPR001789; Sig_transdc_resp-reg_receiver.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF00072; Response_reg
 PF00486; Trans_reg_C 
SMART
 SM00448; REC
 SM00862; Trans_reg_C 
PROSITE
 PS50110; RESPONSE_REGULATORY 
PRINTS