Tag | Content |
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CPLM ID | CPLM-014802 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | E3 ubiquitin-protein ligase HECTD1 |
Protein Synonyms/Alias | HECT domain-containing protein 1; Protein open mind |
Gene Name | Hectd1 |
Gene Synonyms/Alias | Kiaa1131; Opm |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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1277 | LVRSQVLKYMVPGAR | ubiquitination | [1] | 2273 | LVDLPISKPFFKLMC | ubiquitination | [1] | 2613 | LLAATMEKGFHLN** | ubiquitination | [1] |
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Reference | [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C. Nat Cell Biol. 2012 Oct;14(10):1089-98. [ PMID: 23000965] |
Functional Description | Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in development of the head mesenchyme and neural tube closure. |
Sequence Annotation | REPEAT 396 425 ANK 1. REPEAT 427 456 ANK 2. REPEAT 460 492 ANK 3. REPEAT 580 613 ANK 4. DOMAIN 1271 1343 MIB/HERC2. DOMAIN 2156 2618 HECT. REGION 2034 2108 K-box (By similarity). ACT_SITE 2587 2587 Glycyl thioester intermediate (By MOD_RES 632 632 Phosphoserine (By similarity). MOD_RES 1395 1395 Phosphoserine. MOD_RES 1493 1493 Phosphoserine (By similarity). |
Keyword | ANK repeat; Complete proteome; Ligase; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 2618 AA |
Protein Sequence | MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP RTFLPALCKI 60 FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK ALCNRLVVVE LNNRTSRDLA 120 EQCVKVLELI CTRESGAVFE AGGLNCVLTF IRDSGHLVHK DTLHSAMAVV SRLCGKMEPQ 180 DSSLEICVES LSSLLKHEDH QVSDGALRCF ASLADRFTRR GVDPAPLAKH GLTEELLSRM 240 AAAGGTVSGP SSACKPGRST TGAPSAAADS KLSNQVSTIV SLLSTLCRGS PLVTHDLLRS 300 ELPDSIESAL QGDERCVLDT MRLVDLLLVL LFEGRKALPK SSAGSTGRIP GLRRLDSSGE 360 RSHRQLIDCI RSKDTDALID AIDTGAAFEV NFMDDVGQTL LNWASAFGTQ EMVEFLCERG 420 ADVNRGQRSS SLHYAACFGR PQVAKTLLRH GANPDLRDED GKTPLDKARE RGHSEVVAIL 480 QSPGDWMCPV NKGDDKKKKD TNKDEEECNE PRGDPEMAPL YLKRLLPVFA QTFQHTMLPS 540 IRKASLALIR KMIHFCSEAL LKEVCDSDVG HNLPTTLVEI TATVLDQEDD DDGHLLALQI 600 IRDLVDKGGD IFLDQLARLG VISKVSALAG PSSDDENEEE SKPEKEDEPQ EDAKELQQGK 660 PYHWRDWSII RGRDCLYIWS DAAALELSNG SNGWFRFILD GKLATMYSSG SPEGGSDSSE 720 SRSEFLEKLQ RARGQVKPST SSQPILSAPG PTKLTVGNWS LTCLKEGEIA IHNSDGQQAT 780 ILKEDLPGFV FESNRGTKHS FTAETSLGSE FVTGWTGKRG RKLKSKLEKT KQKVRTMARD 840 LYDDHFKAVE SMPRGVVVTL RNIATQLESS WELHTNRQCI EGENTWRDLM KTALENLIVL 900 LKDENTISPY EMCSSGLVQA LLTVLNNVSI FRATKQKQNE VLVERINVFK TAFSESEDDE 960 SYSRPAVALI RKLIAVLESI ERLPLHLYDT PGSTYNLQIL TRRLRFRLER APGETSLIDR 1020 TGRMLKMEPL ATVESLEQYL LKMVAKQWYD FDRSSFVFVR KLREGQNFIF RHQHDFDENG 1080 IIYWIGTNAK TAYEWVNPAA YGLVVVTSSE GRNLPYGRLE DILSRDNSAL NCHSNDDKNA 1140 WFAIDLGVWV IPSAYTLRHA RGYGRSALRN WVFQVSKDGQ NWTSLYTHVD DCSLNEPGST 1200 ATWPLDPAKD EKQGWRHVRL KQMGKNASGQ THYLSLSGFE LYGTVNGVCE DQLGKAAKEA 1260 EANLRRQRRL VRSQVLKYMV PGARVIRGLD WKWRDQDGSP QGEGTVTGEL HNGWIDVTWD 1320 AGGSNSYRMG AEGKFDLKLA PGYDPDTVAS PKPVSSTVSG TTQSWSSLVK NNCPDKTSAA 1380 AGSSSRKGSS SSVCSVASSS DISLASTKTE RRSEIVMEHS IVSGADVHEP IVVLSSAENV 1440 PQTEVGSSSS ASTSTLTAET GSENAERKLG PDSSVRAPGE SSAISMGIVS VSSPDVSSVS 1500 ELTNKEAASQ RPLSSSASNR LSVSSLLAAG APMSSSASVP NLSSRETSSL ESFVRRVANI 1560 ARTNATNNMN LSRSSSDNNT NTLGRNVMST ATSPLMGAQS FPNLTTPGTT STVTMSTSSV 1620 TSSSNVATAT TVLSVGQSLS NTLTTSLTST SSESDTGQEA EYSLYDFLDS CRASTLLAEL 1680 DDDEDLPEPD EEDDENEDDN QEDQEYEEVM ILRRPSLQRR AGSRSDVTHH VVTSQLPQVP 1740 SGAGSRPVGE QEEEEYETKG GRRRAWDDDY VLKRQFSALV PAFDPRPGRT NVQQTTDLEI 1800 PPPGTPHSEL LEEVECTPSP RLALTLKVTG LGTTREVELP LTNFRSTIFY YVQKLLQLSC 1860 NGNVKSDKLR RIWEPTYTIM YREMKDSDKE KENGKMGCWS IEHVEQYLGT DELPKNDLIT 1920 YLQKNADAAF LRHWKLTGTN KSIRKNRNCS QLIAAYKDFC EHGTKSGLNQ GAISSLQSSD 1980 ILNLTKEQPQ AKAGNGQSPC GVEDVLQLLR ILYIVASDPY SRISQEDGDE QPQFTFPPDE 2040 FTSKKITTKI LQQIEEPLAL ASGALPDWCE QLTSKCPFLI PFETRQLYFT CTAFGASRAI 2100 VWLQNRREAT VERTRTTSSV RRDDPGEFRV GRLKHERVKV PRGESLMEWA ENVMQIHADR 2160 KSVLEVEFLG EEGTGLGPTL EFYALVAAEF QRTDLGTWLC DDNFPDDESR HVDLGGGLKP 2220 PGYYVQRSCG LFTAPFPQDS DELERITKLF HFLGIFLAKC IQDNRLVDLP ISKPFFKLMC 2280 MGDIKSNMSK LIYESRGDRD LHCTESQSEA STEEGHDSLS VGSFEEDSKS EFILDPPKPK 2340 PPAWFNGILT WEDFELVNPH RARFLKEIKD LAIKRRQILG NKSLSEDEKN TKLQELVLRN 2400 PSGSGPPLSI EDLGLNFQFC PSSRIYGFTA VDLKPSGEDE MITMDNAEEY VDLMFDFCMH 2460 TGIQKQMEAF RGNVDGFNKV FPMEKLSSFS HEEVQMILCG NQSPSWAAED IINYTEPKLG 2520 YTRDSPGFLR FVRVLCGMSS DERKAFLQFT TGCSTLPPGG LANLHPRLTV VRKVDATDAS 2580 YPSVNTCVHY LKLPEYSSEE IMRERLLAAT MEKGFHLN 2618 |
Gene Ontology | GO:0005737; C:cytoplasm; IBA:RefGenome. GO:0005634; C:nucleus; IBA:RefGenome. GO:0046872; F:metal ion binding; IEA:InterPro. GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. GO:0001843; P:neural tube closure; IMP:UniProtKB. GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. |
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