CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014802
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 E3 ubiquitin-protein ligase HECTD1 
Protein Synonyms/Alias
 HECT domain-containing protein 1; Protein open mind 
Gene Name
 Hectd1 
Gene Synonyms/Alias
 Kiaa1131; Opm 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1277LVRSQVLKYMVPGARubiquitination[1]
2273LVDLPISKPFFKLMCubiquitination[1]
2613LLAATMEKGFHLN**ubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965
Functional Description
 Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in development of the head mesenchyme and neural tube closure. 
Sequence Annotation
 REPEAT 396 425 ANK 1.
 REPEAT 427 456 ANK 2.
 REPEAT 460 492 ANK 3.
 REPEAT 580 613 ANK 4.
 DOMAIN 1271 1343 MIB/HERC2.
 DOMAIN 2156 2618 HECT.
 REGION 2034 2108 K-box (By similarity).
 ACT_SITE 2587 2587 Glycyl thioester intermediate (By
 MOD_RES 632 632 Phosphoserine (By similarity).
 MOD_RES 1395 1395 Phosphoserine.
 MOD_RES 1493 1493 Phosphoserine (By similarity).  
Keyword
 ANK repeat; Complete proteome; Ligase; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2618 AA 
Protein Sequence
MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP RTFLPALCKI 60
FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK ALCNRLVVVE LNNRTSRDLA 120
EQCVKVLELI CTRESGAVFE AGGLNCVLTF IRDSGHLVHK DTLHSAMAVV SRLCGKMEPQ 180
DSSLEICVES LSSLLKHEDH QVSDGALRCF ASLADRFTRR GVDPAPLAKH GLTEELLSRM 240
AAAGGTVSGP SSACKPGRST TGAPSAAADS KLSNQVSTIV SLLSTLCRGS PLVTHDLLRS 300
ELPDSIESAL QGDERCVLDT MRLVDLLLVL LFEGRKALPK SSAGSTGRIP GLRRLDSSGE 360
RSHRQLIDCI RSKDTDALID AIDTGAAFEV NFMDDVGQTL LNWASAFGTQ EMVEFLCERG 420
ADVNRGQRSS SLHYAACFGR PQVAKTLLRH GANPDLRDED GKTPLDKARE RGHSEVVAIL 480
QSPGDWMCPV NKGDDKKKKD TNKDEEECNE PRGDPEMAPL YLKRLLPVFA QTFQHTMLPS 540
IRKASLALIR KMIHFCSEAL LKEVCDSDVG HNLPTTLVEI TATVLDQEDD DDGHLLALQI 600
IRDLVDKGGD IFLDQLARLG VISKVSALAG PSSDDENEEE SKPEKEDEPQ EDAKELQQGK 660
PYHWRDWSII RGRDCLYIWS DAAALELSNG SNGWFRFILD GKLATMYSSG SPEGGSDSSE 720
SRSEFLEKLQ RARGQVKPST SSQPILSAPG PTKLTVGNWS LTCLKEGEIA IHNSDGQQAT 780
ILKEDLPGFV FESNRGTKHS FTAETSLGSE FVTGWTGKRG RKLKSKLEKT KQKVRTMARD 840
LYDDHFKAVE SMPRGVVVTL RNIATQLESS WELHTNRQCI EGENTWRDLM KTALENLIVL 900
LKDENTISPY EMCSSGLVQA LLTVLNNVSI FRATKQKQNE VLVERINVFK TAFSESEDDE 960
SYSRPAVALI RKLIAVLESI ERLPLHLYDT PGSTYNLQIL TRRLRFRLER APGETSLIDR 1020
TGRMLKMEPL ATVESLEQYL LKMVAKQWYD FDRSSFVFVR KLREGQNFIF RHQHDFDENG 1080
IIYWIGTNAK TAYEWVNPAA YGLVVVTSSE GRNLPYGRLE DILSRDNSAL NCHSNDDKNA 1140
WFAIDLGVWV IPSAYTLRHA RGYGRSALRN WVFQVSKDGQ NWTSLYTHVD DCSLNEPGST 1200
ATWPLDPAKD EKQGWRHVRL KQMGKNASGQ THYLSLSGFE LYGTVNGVCE DQLGKAAKEA 1260
EANLRRQRRL VRSQVLKYMV PGARVIRGLD WKWRDQDGSP QGEGTVTGEL HNGWIDVTWD 1320
AGGSNSYRMG AEGKFDLKLA PGYDPDTVAS PKPVSSTVSG TTQSWSSLVK NNCPDKTSAA 1380
AGSSSRKGSS SSVCSVASSS DISLASTKTE RRSEIVMEHS IVSGADVHEP IVVLSSAENV 1440
PQTEVGSSSS ASTSTLTAET GSENAERKLG PDSSVRAPGE SSAISMGIVS VSSPDVSSVS 1500
ELTNKEAASQ RPLSSSASNR LSVSSLLAAG APMSSSASVP NLSSRETSSL ESFVRRVANI 1560
ARTNATNNMN LSRSSSDNNT NTLGRNVMST ATSPLMGAQS FPNLTTPGTT STVTMSTSSV 1620
TSSSNVATAT TVLSVGQSLS NTLTTSLTST SSESDTGQEA EYSLYDFLDS CRASTLLAEL 1680
DDDEDLPEPD EEDDENEDDN QEDQEYEEVM ILRRPSLQRR AGSRSDVTHH VVTSQLPQVP 1740
SGAGSRPVGE QEEEEYETKG GRRRAWDDDY VLKRQFSALV PAFDPRPGRT NVQQTTDLEI 1800
PPPGTPHSEL LEEVECTPSP RLALTLKVTG LGTTREVELP LTNFRSTIFY YVQKLLQLSC 1860
NGNVKSDKLR RIWEPTYTIM YREMKDSDKE KENGKMGCWS IEHVEQYLGT DELPKNDLIT 1920
YLQKNADAAF LRHWKLTGTN KSIRKNRNCS QLIAAYKDFC EHGTKSGLNQ GAISSLQSSD 1980
ILNLTKEQPQ AKAGNGQSPC GVEDVLQLLR ILYIVASDPY SRISQEDGDE QPQFTFPPDE 2040
FTSKKITTKI LQQIEEPLAL ASGALPDWCE QLTSKCPFLI PFETRQLYFT CTAFGASRAI 2100
VWLQNRREAT VERTRTTSSV RRDDPGEFRV GRLKHERVKV PRGESLMEWA ENVMQIHADR 2160
KSVLEVEFLG EEGTGLGPTL EFYALVAAEF QRTDLGTWLC DDNFPDDESR HVDLGGGLKP 2220
PGYYVQRSCG LFTAPFPQDS DELERITKLF HFLGIFLAKC IQDNRLVDLP ISKPFFKLMC 2280
MGDIKSNMSK LIYESRGDRD LHCTESQSEA STEEGHDSLS VGSFEEDSKS EFILDPPKPK 2340
PPAWFNGILT WEDFELVNPH RARFLKEIKD LAIKRRQILG NKSLSEDEKN TKLQELVLRN 2400
PSGSGPPLSI EDLGLNFQFC PSSRIYGFTA VDLKPSGEDE MITMDNAEEY VDLMFDFCMH 2460
TGIQKQMEAF RGNVDGFNKV FPMEKLSSFS HEEVQMILCG NQSPSWAAED IINYTEPKLG 2520
YTRDSPGFLR FVRVLCGMSS DERKAFLQFT TGCSTLPPGG LANLHPRLTV VRKVDATDAS 2580
YPSVNTCVHY LKLPEYSSEE IMRERLLAAT MEKGFHLN 2618 
Gene Ontology
 GO:0005737; C:cytoplasm; IBA:RefGenome.
 GO:0005634; C:nucleus; IBA:RefGenome.
 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome.
 GO:0001843; P:neural tube closure; IMP:UniProtKB.
 GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR008979; Galactose-bd-like.
 IPR000569; HECT.
 IPR010606; Mib_Herc2.
 IPR012919; Sad1_UNC_C. 
Pfam
 PF12796; Ank_2
 PF00632; HECT
 PF06701; MIB_HERC2
 PF07738; Sad1_UNC 
SMART
 SM00248; ANK
 SM00119; HECTc 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS50237; HECT
 PS51416; MIB_HERC2 
PRINTS