UniProt Accession

 RAP1A_HUMAN; P62834; P10113 

Genbank Protein ID

 X12533; M22995; AF493912; AL049557; BC014086 

Genbank Nucleotide ID

 CAA31051.1; AAA36150.1; AAM12626.1; CAB55685.2; AAH14086.1 

Protein Name

 Ras-related protein Rap-1A 

Protein Synonyms/Alias

 C21KG; G-22K; GTP-binding protein smg p21A; Ras-related protein Krev-1 

Gene Name

 RAP1A 

Gene Synonyms/Alias

 KREV1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
151	LESSAKSKINVNEIF	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. 

Sequence Annotation

 NP_BIND 10 17 GTP (By similarity).
 NP_BIND 57 61 GTP (By similarity).
 NP_BIND 116 119 GTP (By similarity).
 MOTIF 32 40 Effector region (Probable).
 MOD_RES 181 181 Cysteine methyl ester.
 LIPID 181 181 S-geranylgeranyl cysteine.  

Keyword

 3D-structure; Cell membrane; Complete proteome; Direct protein sequencing; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Prenylation; Reference proteome; Tumor suppressor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 184 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0032045; C:guanyl-nucleotide exchange factor complex; IEA:Compara.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; TAS:ProtInc.
 GO:0032403; F:protein complex binding; IDA:UniProtKB.
 GO:0008565; F:protein transporter activity; IDA:UniProtKB.
 GO:0000186; P:activation of MAPKK activity; TAS:Reactome.
 GO:0006112; P:energy reserve metabolic process; TAS:Reactome.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
 GO:0030168; P:platelet activation; TAS:Reactome.
 GO:0050796; P:regulation of insulin secretion; TAS:Reactome.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:Compara. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR020849; Small_GTPase_Ras. 

Pfam

 PF00071; Ras 

SMART

 SM00173; RAS 

PROSITE

 PS51421; RAS 

PRINTS

 PR00449; RASTRNSFRMNG.