CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037461
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Translin 
Protein Synonyms/Alias
  
Gene Name
 TSN 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
51AGFQDIPKRCLKAREubiquitination[1, 2, 3, 4, 5]
182GFRLLNLKNDSLRKRacetylation[6, 7]
182GFRLLNLKNDSLRKRubiquitination[1, 2, 4, 5, 7]
194RKRYDGLKYDVKKVEacetylation[6, 8]
214LSIRGFNKETAAACVubiquitination[5, 7]
Reference
 [1] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [6] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [7] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [8] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 223 AA 
Protein Sequence
MPVIPAFWEA EAARSPEEIR KVVQSLEQTA REILTLLQGV HQGAGFQDIP KRCLKAREHF 60
GTVKTHLTSL KTKFPAEQYY RFHEHWRFVL QRLVFLAAFV VYLETETLVT REAVTEILGI 120
EPDREKGFHL DVEDYLSGVL ILASELSRLS VNSVTAGDYS RPLHISTFIN ELDSGFRLLN 180
LKNDSLRKRY DGLKYDVKKV EEVVYDLSIR GFNKETAAAC VEK 223 
Gene Ontology
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. 
Interpro
 IPR002848; Translin.
 IPR016069; Translin_C.
 IPR016068; Translin_N. 
Pfam
 PF01997; Translin 
SMART
  
PROSITE
  
PRINTS