UniProt Accession

 G3UZ44_MOUSE; G3UZ44 

Genbank Protein ID

 AC120173 

Genbank Nucleotide ID

  

Protein Name

 Paired mesoderm homeobox protein 1 

Protein Synonyms/Alias

  

Gene Name

 Prrx1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
160	ERAMLANKNASLLKS	acetylation	[1, 2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; DNA-binding; Homeobox; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 200 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:MGI.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0048844; P:artery morphogenesis; IMP:MGI.
 GO:0051216; P:cartilage development; IMP:MGI.
 GO:0048701; P:embryonic cranial skeleton morphogenesis; IMP:MGI.
 GO:0030326; P:embryonic limb morphogenesis; IGI:MGI.
 GO:0042472; P:inner ear morphogenesis; IGI:MGI.
 GO:0042474; P:middle ear morphogenesis; IMP:MGI.
 GO:0060021; P:palate development; IMP:MGI.
 GO:0002053; P:positive regulation of mesenchymal cell proliferation; IGI:MGI.
 GO:0045880; P:positive regulation of smoothened signaling pathway; IGI:MGI. 

Interpro

 IPR017970; Homeobox_CS.
 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like. 

Pfam

 PF00046; Homeobox 

SMART

 SM00389; HOX 

PROSITE

 PS00027; HOMEOBOX_1
 PS50071; HOMEOBOX_2 

PRINTS