CPLM-018605

Genbank Nucleotide ID

UTP--glucose-1-phosphate uridylyltransferase

Protein Synonyms/Alias

UDP-glucose pyrophosphorylase; UDPGP; UGPase

Mus musculus (Mouse)

Position	Peptide	Type	References
38	SVKKELEKILTTAAS	ubiquitination	[1]
52	SHEFEHTKKDLDGFR	ubiquitination	[1]
53	HEFEHTKKDLDGFRK	ubiquitination	[1]
69	FHRFLQEKGPSVDWG	ubiquitination	[1]
77	GPSVDWGKIQRPPED	ubiquitination	[1]
91	DSIQPYEKIKARGLP	acetylation	[2, 3, 4, 5]
91	DSIQPYEKIKARGLP	succinylation	[5]
91	DSIQPYEKIKARGLP	ubiquitination	[1]
107	NISSVLNKLVVVKLN	ubiquitination	[1]
124	LGTSMGCKGPKSLIG	ubiquitination	[1]
172	FNTDEDTKKILQKYN	ubiquitination	[1]
184	KYNHCRVKIYTFNQS	acetylation	[6]
184	KYNHCRVKIYTFNQS	ubiquitination	[1]
198	SRYPRINKESLLPIA	ubiquitination	[1]
291	NKTRADVKGGTLTQY	acetylation	[2]
291	NKTRADVKGGTLTQY	ubiquitination	[1]
312	VEIAQVPKAHVDEFK	ubiquitination	[1]
319	KAHVDEFKSVSKFKI	acetylation	[2, 3, 6]
319	KAHVDEFKSVSKFKI	ubiquitination	[1]
421	GSLTMSEKREFPTVP	ubiquitination	[1]
431	FPTVPLVKLGSSFTK	ubiquitination	[1]
438	KLGSSFTKVQDYLRR	acetylation	[3, 4]
438	KLGSSFTKVQDYLRR	ubiquitination	[1]
497	PGAVLENKIVSGNLR	ubiquitination	[1]

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
[2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
Simon GM, Cheng J, Gordon JI.
Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
[3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
[4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
PLoS One. 2012;7(12):e50545. [PMID: 23236377]
[5] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
[6] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]

Functional Description

Plays a central role as a glucosyl donor in cellular metabolic pathways.

REGION 457 508 Oligomerization (By similarity).
REGION 502 503 Critical for end-to-end subunit
ACT_SITE 396 396 By similarity.
METAL 127 127 Magnesium (By similarity).
METAL 253 253 Magnesium (By similarity).
MOD_RES 13 13 Phosphoserine (By similarity).
MOD_RES 438 438 N6-acetyllysine (By similarity).

Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Magnesium; Metal-binding; Nucleotidyltransferase; Phosphoprotein; Reference proteome; Transferase.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase activity; IEA:EC.

IPR002618; UDPGP_trans.
IPR016267; UDPGP_trans_subgr.