UniProt Accession

 C9JB29_HUMAN; C9JB29 

Genbank Protein ID

 AC007256; AC007283 

Genbank Nucleotide ID

  

Protein Name

 Caspase-8 subunit p10 

Protein Synonyms/Alias

  

Gene Name

 CASP8 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
18	RSELRSFKFLLQEEI	ubiquitination	[1]
27	LLQEEISKCKLDDDM	ubiquitination	[1]
45	DIFIEMEKRVILGEG	ubiquitination	[2]
53	RVILGEGKLDILKRV	ubiquitination	[1]
66	RVCAQINKSLLKIIN	ubiquitination	[1]
106	SESQTLDKVYQMKSK	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A data set of human endogenous protein ubiquitination sites.
 Shi Y, Chan DW, Jung SY, Malovannaya A, Wang Y, Qin J.
 Mol Cell Proteomics. 2011 May;10(5):M110.002089. [PMID: 20972266] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 149 AA 

Protein Sequence

Gene Ontology

 GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:InterPro.
 GO:0042981; P:regulation of apoptotic process; IEA:InterPro. 

Interpro

 IPR011029; DEATH-like_dom.
 IPR001875; DED.
 IPR001309; Pept_C14_ICE_p20.
 IPR002398; Pept_C14_p45. 

Pfam

 PF01335; DED 

SMART

 SM00031; DED 

PROSITE

 PS50208; CASPASE_P20
 PS50168; DED 

PRINTS