UniProt Accession

 TXD17_MOUSE; Q9CQM5; Q3TE14; Q921A9; Q9D0Y4 

Genbank Protein ID

 AJ344103; AK004219; AK007595; AK013103; AK076425; AK169882; BX119911; BC030344 

Genbank Nucleotide ID

 CAC51438.1; BAB23225.1; BAB25126.1; BAB28648.1; BAC36336.1; BAE41434.1; CAI24478.1; AAH30344.1 

Protein Name

 Thioredoxin domain-containing protein 17 

Protein Synonyms/Alias

 14 kDa thioredoxin-related protein; TRP14; Protein 42-9-9; Thioredoxin-like protein 5 

Gene Name

 Txndc17 

Gene Synonyms/Alias

 Txnl5 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
74	IYCQVGDKPYWKDPN	acetylation	[1]
98	TAVPTLLKYGTPQKL	acetylation	[1]
98	TAVPTLLKYGTPQKL	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide (By similarity). 

Sequence Annotation

 DOMAIN 41 123 Thioredoxin.
 ACT_SITE 43 43 Nucleophile (By similarity).
 ACT_SITE 46 46 Nucleophile (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 DISULFID 43 46 Redox-active (By similarity).  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Disulfide bond; Redox-active center; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 123 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0009055; F:electron carrier activity; IEA:Compara.
 GO:0004601; F:peroxidase activity; IEA:Compara.
 GO:0047134; F:protein-disulfide reductase activity; IEA:Compara.
 GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IEA:Compara. 

Interpro

 IPR010357; DUF953_thioredox.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF06110; DUF953 

SMART

  

PROSITE

 PS00194; THIOREDOXIN_1
 PS51352; THIOREDOXIN_2 

PRINTS