UniProt Accession

 ACD_HUMAN; Q96AP0; Q562H5; Q9H8F9 

Genbank Protein ID

 AY502940; AK023726; AC010530; BC016904; AY971883 

Genbank Nucleotide ID

 AAS80318.1; BAB14658.1; AAH16904.1; AAX82621.1 

Protein Name

 Adrenocortical dysplasia protein homolog 

Protein Synonyms/Alias

 POT1 and TIN2-interacting protein 

Gene Name

 ACD 

Gene Synonyms/Alias

 PIP1; PTOP; TINT1; TPP1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
170	DTSDWEEKEFGFRGT	ubiquitination	[1, 2]
232	NQDLDVQKKLYDCLE	ubiquitination	[2, 3]
233	QDLDVQKKLYDCLEE	ubiquitination	[2]
467	EFVGLPCKNRPPFPR	ubiquitination	[2, 3]
492	CSVWEPPKRHRDGSA	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity. Plays a role in shelterin complex assembly. May play a role in organogenesis. 

Sequence Annotation

 REGION 244 337 Interaction with POT1.
 MOTIF 97 99 PWI.
 MOD_RES 111 111 Phosphoserine.  

Keyword

 3D-structure; Alternative splicing; Chromosome; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Telomere. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 544 AA 

Protein Sequence

Gene Ontology

 GO:0000783; C:nuclear telomere cap complex; IDA:BHF-UCL.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0005697; C:telomerase holoenzyme complex; IEA:InterPro.
 GO:0042162; F:telomeric DNA binding; IEA:InterPro.
 GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
 GO:0030326; P:embryonic limb morphogenesis; IEA:Compara.
 GO:0006886; P:intracellular protein transport; IMP:BHF-UCL.
 GO:0032211; P:negative regulation of telomere maintenance via telomerase; IMP:BHF-UCL.
 GO:0060381; P:positive regulation of single-stranded telomeric DNA binding; IDA:BHF-UCL.
 GO:0051973; P:positive regulation of telomerase activity; IDA:BHF-UCL.
 GO:0031848; P:protection from non-homologous end joining at telomere; ISS:BHF-UCL.
 GO:0070198; P:protein localization to chromosome, telomeric region; IMP:BHF-UCL.
 GO:0035282; P:segmentation; IEA:Compara.
 GO:0001501; P:skeletal system development; IEA:Compara.
 GO:0032202; P:telomere assembly; IMP:BHF-UCL.
 GO:0007004; P:telomere maintenance via telomerase; IEA:InterPro.
 GO:0001655; P:urogenital system development; IEA:Compara. 

Interpro

 IPR021594; Telomere_Pot1. 

Pfam

 PF11509; Telomere_Pot1 

SMART

  

PROSITE

  

PRINTS