UniProt Accession

 APOC2_MOUSE; Q05020 

Genbank Protein ID

 Z15090; Z22216; Z22217; BC024697 

Genbank Nucleotide ID

 CAA78804.1; CAA80220.1; CAA80220.1; AAH24697.1 

Protein Name

 Apolipoprotein C-II 

Protein Synonyms/Alias

 Apo-CII; ApoC-II; Apolipoprotein C2 

Gene Name

 Apoc2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
67	YPISMDEKLRDMYSK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly. 

Sequence Annotation

 REGION 40 48 Lipid binding (By similarity).
 REGION 52 75 Lipoprotein lipase cofactor (By  

Keyword

 Chylomicron; Complete proteome; Lipid degradation; Lipid metabolism; Lipid transport; Reference proteome; Secreted; Signal; Transport; VLDL. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 97 AA 

Protein Sequence

Gene Ontology

 GO:0042627; C:chylomicron; IEA:UniProtKB-KW.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005576; C:extracellular region; TAS:Reactome.
 GO:0034363; C:intermediate-density lipoprotein particle; IEA:Compara.
 GO:0034362; C:low-density lipoprotein particle; IEA:Compara.
 GO:0034366; C:spherical high-density lipoprotein particle; IEA:Compara.
 GO:0034361; C:very-low-density lipoprotein particle; IEA:UniProtKB-KW.
 GO:0055102; F:lipase inhibitor activity; IEA:Compara.
 GO:0008289; F:lipid binding; IEA:Compara.
 GO:0060230; F:lipoprotein lipase activator activity; IEA:Compara.
 GO:0016004; F:phospholipase activator activity; IEA:Compara.
 GO:0033344; P:cholesterol efflux; IEA:Compara.
 GO:0034382; P:chylomicron remnant clearance; IEA:Compara.
 GO:0034384; P:high-density lipoprotein particle clearance; IEA:Compara.
 GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
 GO:0042953; P:lipoprotein transport; IEA:Compara.
 GO:0032375; P:negative regulation of cholesterol transport; IEA:Compara.
 GO:0045833; P:negative regulation of lipid metabolic process; IEA:Compara.
 GO:0048261; P:negative regulation of receptor-mediated endocytosis; IEA:Compara.
 GO:0010916; P:negative regulation of very-low-density lipoprotein particle clearance; IEA:Compara.
 GO:0033700; P:phospholipid efflux; IEA:Compara.
 GO:0045723; P:positive regulation of fatty acid biosynthetic process; IEA:Compara.
 GO:0051006; P:positive regulation of lipoprotein lipase activity; IEA:Compara.
 GO:0010518; P:positive regulation of phospholipase activity; IEA:Compara.
 GO:0060697; P:positive regulation of phospholipid catabolic process; IEA:Compara.
 GO:0010898; P:positive regulation of triglyceride catabolic process; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0070328; P:triglyceride homeostasis; IEA:Compara. 

Interpro

 IPR008019; Apo-CII.
 IPR023121; ApoC-II_domain. 

Pfam

 PF05355; Apo-CII 

SMART

  

PROSITE

  

PRINTS