CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015678
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Up-regulated during skeletal muscle growth protein 5 
Protein Synonyms/Alias
 Diabetes-associated protein in insulin-sensitive tissues 
Gene Name
 Usmg5 
Gene Synonyms/Alias
 Dapit 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
16QFQFTGIKKYFNSYTacetylation[1, 2, 3, 4, 5]
16QFQFTGIKKYFNSYTsuccinylation[4]
16QFQFTGIKKYFNSYTubiquitination[6]
17FQFTGIKKYFNSYTLacetylation[1, 3]
17FQFTGIKKYFNSYTLubiquitination[6]
Reference
 [1] Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
 Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y.
 Mol Cell. 2006 Aug;23(4):607-18. [PMID: 16916647]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [5] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [6] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Plays a critical role in maintaining the ATP synthase population in mitochondria (By similarity). 
Sequence Annotation
 MOD_RES 16 16 N6-acetyllysine.
 MOD_RES 17 17 N6-acetyllysine.  
Keyword
 Acetylation; Complete proteome; Membrane; Mitochondrion; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 58 AA 
Protein Sequence
MAGAESDGQF QFTGIKKYFN SYTLTGRMNC VLATYGGIAL LVLYFKLRPK KTPAVKAT 58 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005753; C:mitochondrial proton-transporting ATP synthase complex; ISS:UniProtKB. 
Interpro
 IPR009125; DAPIT. 
Pfam
  
SMART
  
PROSITE
  
PRINTS
 PR01821; DAPIT.