| Tag | Content |
|---|
| CPLM ID | CPLM-001342 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 60 kDa lysophospholipase |
Protein Synonyms/Alias | L-asparaginase; L-asparagine amidohydrolase; Platelet-activating factor acetylhydrolase; PAF acetylhydrolase |
Gene Name | Aspg |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 354 | DRKKLLAKDLRGEMT | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities. |
Sequence Annotation | REPEAT 141 170 ANK 1.
REPEAT 396 426 ANK 2.
REPEAT 430 459 ANK 3.
REPEAT 463 492 ANK 4.
REPEAT 530 559 ANK 5.
REGION 41 350 Asparaginase.
REGION 84 86 Substrate binding (By similarity).
REGION 116 117 Substrate binding (By similarity).
ACT_SITE 19 19 Acyl-ester intermediate (By similarity).
MOD_RES 387 387 Phosphoserine (By similarity). |
Keyword | ANK repeat; Complete proteome; Direct protein sequencing; Hydrolase; Lipid degradation; Lipid metabolism; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 564 AA |
Protein Sequence | MARATGPEQR LLAIYTGGTI GMRSEGGVLV PGRGLAAVLR TLHMLHDEEY ARAHSLPEDT 60
LVLPPASSDQ RIIYKVLECQ PLFDSSDMTI TEWVQIAQTI ERHYTQYQGF VVIHGTDTMA 120
FAASVLSFML ENLQKPVILT GAQVPIHELW SDGRENLLGA LLMAGQYVIP EVCLFFQNQL 180
FRGNRTTKVD ARRFAAFCSP NLPPLATVGA DVTINRELVR KASWKSHLVV HSNMEPDVGL 240
LRLYPGIPAS LVRTFLQPPL KGVVMETFGS GNGPTKPDLI QELRAAAERG LIIVNCTHCL 300
QGAVTSDYAP GMAMAGAGII SGFDMTSEAA LAKLSYVLGQ PGLSLSDRKK LLAKDLRGEM 360
TLPTTDDLLG DDMLGCRATW LLSMNGSQDA DAMKDVLLPG LALAAAHAGD LDTLQAFVEL 420
GRDLNLKDYS GQTPLHVAAR RGHASVVAML LQKGVDVDAC NEDGQSPLLL AVRGRHQSVI 480
RLLRAAGAHL SPQELEDVGT ELCRLASRAD SEGLRAWWQA GADLGQPDYD GHCALQVAEA 540
AGNADVVALL QSLEDRVSAQ PQPH 564 |
Gene Ontology | GO:0003847; F:1-alkyl-2-acetylglycerophosphocholine esterase activity; IMP:RGD. GO:0004067; F:asparaginase activity; IDA:UniProtKB. GO:0004622; F:lysophospholipase activity; IDA:UniProtKB. GO:0006528; P:asparagine metabolic process; IDA:UniProtKB. GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. GO:0006644; P:phospholipid metabolic process; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |