UniProt Accession

 PGK2_MOUSE; P09041; Q5RKV3; Q6P8V2 

Genbank Protein ID

 M17299; M18654; AK133436; CH466559; BC052343; BC061054; X55310 

Genbank Nucleotide ID

 AAA39920.1; AAA39921.1; BAE21656.1; EDL23381.1; AAH52343.1; AAH61054.1; CAA39014.1 

Protein Name

 Phosphoglycerate kinase 2 

Protein Synonyms/Alias

 Phosphoglycerate kinase, testis specific 

Gene Name

 Pgk2 

Gene Synonyms/Alias

 Pgk-2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
11	SAKLTLDKVDLKGKR	ubiquitination	[1]
30	VDFNVPMKNNQITNN	acetylation	[2, 3, 4]
30	VDFNVPMKNNQITNN	succinylation	[4]
30	VDFNVPMKNNQITNN	ubiquitination	[1]
131	FHVEEEGKGKDSSGK	acetylation	[2, 4, 5]
156	AFQASLSKLGDVYVN	acetylation	[3, 6]
156	AFQASLSKLGDVYVN	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [5] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [6] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

  

Sequence Annotation

 NP_BIND 373 376 ATP (By similarity).
 REGION 24 26 Substrate binding (By similarity).
 REGION 63 66 Substrate binding (By similarity).
 BINDING 39 39 Substrate (By similarity).
 BINDING 123 123 Substrate (By similarity).
 BINDING 171 171 Substrate (By similarity).
 BINDING 220 220 ATP (By similarity).
 BINDING 313 313 ATP; via carbonyl oxygen (By similarity).
 BINDING 344 344 ATP (By similarity).  

Keyword

 3D-structure; ATP-binding; Complete proteome; Cytoplasm; Glycolysis; Kinase; Nucleotide-binding; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 417 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; ISS:UniProtKB.
 GO:0004618; F:phosphoglycerate kinase activity; ISS:UniProtKB.
 GO:0006096; P:glycolysis; IEA:UniProtKB-UniPathway. 

Interpro

 IPR001576; Phosphoglycerate_kinase.
 IPR015901; Phosphoglycerate_kinase_C.
 IPR015911; Phosphoglycerate_kinase_CS.
 IPR015824; Phosphoglycerate_kinase_N. 

Pfam

 PF00162; PGK 

SMART

  

PROSITE

 PS00111; PGLYCERATE_KINASE 

PRINTS

 PR00477; PHGLYCKINASE.