CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019254
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein bicaudal D homolog 1 
Protein Synonyms/Alias
 Bic-D 1 
Gene Name
 BICD1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
22TEIERLTKELTETTHubiquitination[1]
117LEMQNELKQSRAVVTubiquitination[1]
443ALKEKYNKSVENYTDubiquitination[1]
485EKMAHMEKELQKMTSubiquitination[1]
684LKSLLSTKREQIATLubiquitination[1]
787LRMAIQQKLALTQRLubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Regulates coat complex coatomer protein I (COPI)- independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex. 
Sequence Annotation
 REGION 663 803 Interacts with RAB6A.  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Golgi apparatus; Host-virus interaction; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 975 AA 
Protein Sequence
MAAEEVLQTV DHYKTEIERL TKELTETTHE KIQAAEYGLV VLEEKLTLKQ QYDELEAEYD 60
SLKQELEQLK EAFGQSFSIH RKVAEDGETR EETLLQESAS KEAYYLGKIL EMQNELKQSR 120
AVVTNVQAEN ERLTAVVQDL KENNEMVELQ RIRMKDEIRE YKFREARLLQ DYTELEEENI 180
TLQKLVSTLK QNQVEYEGLK HEIKRFEEET VLLNSQLEDA IRLKEIAEHQ LEEALETLKN 240
EREQKNNLRK ELSQYISLND NHISISVDGL KFAEDGSEPN NDDKMNGHIH GPLVKLNGDY 300
RTPTLRKGES LNPVSDLFSE LNISEIQKLK QQLMQVEREK AILLANLQES QTQLEHTKGA 360
LTEQHERVHR LTEHVNAMRG LQSSKELKAE LDGEKGRDSG EEAHDYEVDI NGLEILECKY 420
RVAVTEVIDL KAEIKALKEK YNKSVENYTD EKAKYESKIQ MYDEQVTSLE KTTKESGEKM 480
AHMEKELQKM TSIANENHST LNTAQDELVT FSEELAQLYH HVCLCNNETP NRVMLDYYRQ 540
SRVTRSGSLK GPDDPRGLLS PRLARRGVSS PVETRTSSEP VAKESTEASK EPSPTKTPTI 600
SPVITAPPSS PVLDTSDIRK EPMNIYNLNA IIRDQIKHLQ KAVDRSLQLS RQRAAARELA 660
PMIDKDKEAL MEEILKLKSL LSTKREQIAT LRAVLKANKQ TAEVALANLK NKYENEKAMV 720
TETMTKLRNE LKALKEDAAT FSSLRAMFAT RCDEYVTQLD EMQRQLAAAE DEKKTLNTLL 780
RMAIQQKLAL TQRLEDLEFD HEQSRRSKGK LGKSKIGSPK VSGEASVTVP TIDTYLLHSQ 840
GPQTPNIRVS SGTQRKRQFS PSLCDQSRPR TSGASYLQNL LRVPPDPTST ESFLLKGPPS 900
MSEFIQGHRL SKEKRLTVAP PDCQQPAASV PPQCSQLAGR QDCPTVSPDT ALPEEQPHSS 960
SQCAPLHCLS KPPHP 975 
Gene Ontology
 GO:0031410; C:cytoplasmic vesicle; IDA:BHF-UCL.
 GO:0005856; C:cytoskeleton; NAS:UniProtKB.
 GO:0005829; C:cytosol; IDA:BHF-UCL.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0072517; C:host cell viral assembly compartment; IDA:BHF-UCL.
 GO:0016020; C:membrane; IDA:BHF-UCL.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.
 GO:0005802; C:trans-Golgi network; IDA:BHF-UCL.
 GO:0008093; F:cytoskeletal adaptor activity; IDA:BHF-UCL.
 GO:0034452; F:dynactin binding; IDA:BHF-UCL.
 GO:0045502; F:dynein binding; IDA:BHF-UCL.
 GO:0031871; F:proteinase activated receptor binding; ISS:BHF-UCL.
 GO:0005200; F:structural constituent of cytoskeleton; TAS:ProtInc.
 GO:0009653; P:anatomical structure morphogenesis; TAS:ProtInc.
 GO:0008298; P:intracellular mRNA localization; NAS:UniProtKB.
 GO:0072393; P:microtubule anchoring at microtubule organizing center; ISS:BHF-UCL.
 GO:0072385; P:minus-end-directed organelle transport along microtubule; IMP:BHF-UCL.
 GO:1900275; P:negative regulation of phospholipase C activity; ISS:BHF-UCL.
 GO:1900737; P:negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway; ISS:BHF-UCL.
 GO:0048260; P:positive regulation of receptor-mediated endocytosis; IMP:BHF-UCL.
 GO:0033365; P:protein localization to organelle; IDA:BHF-UCL.
 GO:1900276; P:regulation of proteinase activated receptor activity; ISS:BHF-UCL.
 GO:0006396; P:RNA processing; TAS:ProtInc.
 GO:0034063; P:stress granule assembly; ISS:BHF-UCL.
 GO:0016032; P:viral reproduction; IMP:BHF-UCL.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 
Interpro
 IPR018477; Bicaudal-D_microtubule-assoc. 
Pfam
 PF09730; BicD 
SMART
  
PROSITE
  
PRINTS