CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002331
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cell division control protein 7 
Protein Synonyms/Alias
  
Gene Name
 CDC7 
Gene Synonyms/Alias
 OAF2; YDL017W; D2855 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
49GTFSSVYKAKDITGKubiquitination[1]
429AVDAYELKKYQEEIWubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Serine/threonine-protein kinase. Needed for the initiation of DNA synthesis during mitosis as well as for synaptonemal complex formation and commitment to recombination during meiosis. Required for HTA1-HTB1 locus transcription repression. 
Sequence Annotation
 DOMAIN 33 469 Protein kinase.
 NP_BIND 39 47 ATP (By similarity).
 ACT_SITE 163 163 Proton acceptor (By similarity).
 BINDING 76 76 ATP (By similarity).  
Keyword
 ATP-binding; Cell cycle; Cell division; Complete proteome; Kinase; Magnesium; Meiosis; Metal-binding; Mitosis; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 507 AA 
Protein Sequence
MTSKTKNIDD IPPEIKEEMI QLYHDLPGIE NEYKLIDKIG EGTFSSVYKA KDITGKITKK 60
FASHFWNYGS NYVALKKIYV TSSPQRIYNE LNLLYIMTGS SRVAPLCDAK RVRDQVIAVL 120
PYYPHEEFRT FYRDLPIKGI KKYIWELLRA LKFVHSKGII HRDIKPTNFL FNLELGRGVL 180
VDFGLAEAQM DYKSMISSQN DYDNYANTNH DGGYSMRNHE QFCPCIMRNQ YSPNSHNQTP 240
PMVTIQNGKV VHLNNVNGVD LTKGYPKNET RRIKRANRAG TRGFRAPEVL MKCGAQSTKI 300
DIWSVGVILL SLLGRRFPMF QSLDDADSLL ELCTIFGWKE LRKCAALHGL GFEASGLIWD 360
KPNGYSNGLK EFVYDLLNKE CTIGTFPEYS VAFETFGFLQ QELHDRMSIE PQLPDPKTNM 420
DAVDAYELKK YQEEIWSDHY WCFQVLEQCF EMDPQKRSSA EDLLKTPFFN ELNENTYLLD 480
GESTDEDDVV SSSEADLLDK DVLLISE 507 
Gene Ontology
 GO:0031431; C:Dbf4-dependent protein kinase complex; IGI:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IMP:SGD.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0006270; P:DNA replication initiation; IMP:SGD.
 GO:0000727; P:double-strand break repair via break-induced replication; IMP:SGD.
 GO:0007126; P:meiosis; IEA:UniProtKB-KW.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0001100; P:negative regulation of exit from mitosis; IPI:SGD.
 GO:0031938; P:regulation of chromatin silencing at telomere; IMP:SGD. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
  
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS