| Tag | Content |
|---|
| CPLM ID | CPLM-017892 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ubiquitin carboxyl-terminal hydrolase 15 |
Protein Synonyms/Alias | Deubiquitinating enzyme 15; Ubiquitin thioesterase 15; Ubiquitin-specific-processing protease 15 |
Gene Name | Usp15 |
Gene Synonyms/Alias | Kiaa0529 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 231 | GPSTPNVKNSNYCLP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes. According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal. Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP (By similarity). |
Sequence Annotation | DOMAIN 7 118 DUSP.
ACT_SITE 298 298 Nucleophile (By similarity).
ACT_SITE 891 891 Proton acceptor (By similarity).
MOD_RES 2 2 N-acetylalanine (By similarity).
MOD_RES 229 229 Phosphoserine (By similarity).
MOD_RES 242 242 Phosphoserine (By similarity).
MOD_RES 961 961 Phosphoserine (By similarity).
MOD_RES 965 965 Phosphoserine (By similarity). |
Keyword | Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Nucleus; Phosphoprotein; Protease; Reference proteome; Thiol protease; Ubl conjugation; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 981 AA |
Protein Sequence | MAEGGAADLD TQRSDIADAW LKPRSGKGDT WYLVDSRWFK QWKKYVGFDS WDKYQMGDQN 60
VYPGPIDNSG LLKDGDAQSL KEHLIDELDY ILLPTEGWNK LVSWYTLMEG QEPIARKVVE 120
QGMFVKHCKV EVYLTELKLC ENGNMNNVVT RRFSKADTID TIEKEIRKIF NIPDEKEARL 180
WNKYMSNTFE PLNKPDSTIQ DAGLYQGQVL VIEQKNEDGT WPRGPSTPNV KNSNYCLPSY 240
TAYKNYDYSE PGRNNEQPGL CGLSNLGNTC FMNSAIQCLS NTPPLTEYFL NDKYQEELNF 300
DNPLGMRGEI AKSYAELIKQ MWSGKFSYVT PRAFKTQVGR FAPQFSGYQQ QDCQELLAFL 360
LDGLHEDLNR IRKKPYIQLK DADGRPDKVV AEEAWENHLK RNDSIIVDIF HGLFKSTLVC 420
PECAKISVTF DPFCYLTLPL PMKKERSLEV YLVRMDPLAK PMQYKVIVPK IGNILDLCTA 480
LSALSGVPAD KMIVTDIYNH RFHRIFAVDE NLSSIMERDD IYVFEININR AEDTEHVVIP 540
VCLREKFRHS SYTHHTGSSL FGQPFLMAIP RNNTEDKLYN LLLLRMCRYV KMSTETEETD 600
GHLRCCEDQN INGNGPNGLH EEGSPSEMET DEPDDESSQD QELPSENENS QSEDSVGGDN 660
DSENGLCTEE TCKGQLTGHK KRLFTFQFNN LGNNDINYIK DDTSHIRFDD RQLRLDERSF 720
LALDWDPDLK KRYFDENAAE DFEKHESVEY KPPKRPFVKL KDCIELFTTK EKLGAEDPWY 780
CPNCKEHQQA TKKLDLWSLP PVLVVHLKRF SYSRYMRDKL DTLVDFPISD LDMSEFLINP 840
NAGPCRYNLI AVSNHYGGMG GGHYTAFAKN KDDGKWYYFD DSSVSTASED QIVSKAAYVL 900
FYQRQDTFSG TGFFPLDRET KGASAATGIP LESDEDSNDN DNDLENENCM HTN 953 |
Gene Ontology | GO:0005737; C:cytoplasm; ISS:UniProtKB. GO:0005634; C:nucleus; ISS:UniProtKB. GO:0004197; F:cysteine-type endopeptidase activity; ISS:UniProtKB. GO:0004221; F:ubiquitin thiolesterase activity; ISS:UniProtKB. GO:0004843; F:ubiquitin-specific protease activity; ISS:UniProtKB. GO:0030509; P:BMP signaling pathway; ISS:UniProtKB. GO:0035520; P:monoubiquitinated protein deubiquitination; ISS:UniProtKB. GO:0060389; P:pathway-restricted SMAD protein phosphorylation; ISS:UniProtKB. GO:0007179; P:transforming growth factor beta receptor signaling pathway; ISS:UniProtKB. GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |