UniProt Accession

 PIPNA_HUMAN; Q00169 

Genbank Protein ID

 M73704; D30036; BC082976; BC045108 

Genbank Nucleotide ID

 AAA36441.1; BAA06276.1; AAH82976.1; AAH45108.1 

Protein Name

 Phosphatidylinositol transfer protein alpha isoform 

Protein Synonyms/Alias

 PI-TP-alpha; PtdIns transfer protein alpha; PtdInsTP alpha 

Gene Name

 PITPNA 

Gene Synonyms/Alias

 PITPN 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
50	LVNEPYEKDGEKGQY	ubiquitination	[1]
86	GALNIHEKAWNAYPY	ubiquitination	[2]
152	DRSQVLSKDYKAEED	ubiquitination	[2]
162	KAEEDPAKFKSIKTG	ubiquitination	[2]
178	GPLGPNWKQELVNQK	ubiquitination	[1, 2]
201	KLVTVKFKWWGLQNK	ubiquitination	[2]
208	KWWGLQNKVENFIHK	ubiquitination	[2]
215	KVENFIHKQERRLFT	acetylation	[3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes. 

Sequence Annotation

 BINDING 58 58 Phosphatidylinositol lipid headgroup.
 BINDING 60 60 Phosphatidylinositol lipid headgroup.
 BINDING 85 85 Phosphatidylinositol lipid headgroup.
 BINDING 89 89 Phosphatidylinositol lipid headgroup.
 BINDING 96 96 Phosphatidylinositol lipid headgroup.
 BINDING 194 194 Phosphatidylinositol lipid headgroup.
 MOD_RES 215 215 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Lipid-binding; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 270 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0000062; F:fatty-acyl-CoA binding; IEA:Compara.
 GO:0008525; F:phosphatidylcholine transporter activity; TAS:ProtInc.
 GO:0035091; F:phosphatidylinositol binding; IEA:Compara.
 GO:0008526; F:phosphatidylinositol transporter activity; TAS:ProtInc.
 GO:0070540; F:stearic acid binding; IEA:Compara.
 GO:0007411; P:axon guidance; TAS:Reactome.
 GO:0006629; P:lipid metabolic process; NAS:ProtInc.
 GO:0007601; P:visual perception; TAS:ProtInc. 

Interpro

 IPR001666; PI_transfer.
 IPR023393; START-like_dom. 

Pfam

 PF02121; IP_trans 

SMART

  

PROSITE

  

PRINTS

 PR00391; PITRANSFER.