CPLM-017095

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-017095

UniProt Accession

SMAP1_HUMAN; Q8IYB5; Q53H70; Q5SYQ2; Q6PK24; Q8NDH4; Q96L38; Q96L39; Q9H8X4

Genbank Protein ID

AY055003; AY055004; AY055015; AY055005; AY055006; AY055007; AY055008; AY055009; AY055010; AY055011; AY055012; AY055013; AY055014; AY055015; AY055005; AY055006; AY055007; AY055008; AY055010; AY055011; AY055012; AY055013; AY055014; AK023221; AF442495; AK222711; AL354943; AL591049; AL121961; AL354943; AL121961; AL591049; AL354943; AL121961; AL591049; AL591049; AL121961; AL354943; AL591049; AL121961; AL354943; AL591049; AL121961; AL354943; AL121961; AL591049; AL354943; AL121961; AL354943; AL591049; AL121961; AL354943; AL591049; BC008672; BC028074; BC036123; AL833906

Genbank Nucleotide ID

AAL14714.1; AAL14715.1; AAL14716.1; AAL14716.1; AAL14716.1; AAL14716.1; AAL14716.1; AAL14716.1; AAL14716.1; AAL14716.1; AAL14716.1; AAL14716.1; AAL14716.1; AAL14717.1; AAL14717.1; AAL14717.1; AAL14717.1; AAL14717.1; AAL14717.1; AAL14717.1; AAL14717.1; AAL14717.1; AAL14717.1; BAB14473.1; AAP97320.1; BAD96431.1; CAI12310.1; CAI12310.1; CAI12310.1; CAI12311.1; CAI12311.1; CAI12311.1; CAI12312.1; CAI12312.1; CAI12312.1; CAI14240.1; CAI14240.1; CAI14240.1; CAI14241.1; CAI14241.1; CAI14241.1; CAI14242.1; CAI14242.1; CAI14242.1; CAI42146.1; CAI42146.1; CAI42146.1; CAI42147.1; CAI42147.1; CAI42147.1; CAI42148.1; CAI42148.1; CAI42148.1; AAH08672.1; AAH28074.1; AAH36123.1; CAD38762.1

Protein Name

Stromal membrane-associated protein 1

Protein Synonyms/Alias

Gene Name

SMAP1

Gene Synonyms/Alias

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
23	QHQLILSKLLREEDN	ubiquitination	[1, 2]

Reference

[1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
Chen Z, Zhou Y, Song J, Zhang Z.
Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]

Functional Description

GTPase activating protein that acts on ARF6. Plays a role in clathrin-dependent endocytosis. May play a role in erythropoiesis (By similarity).

Sequence Annotation

DOMAIN 18 136 Arf-GAP.
ZN_FING 33 56 C4-type.
MOTIF 218 222 Interaction with clathrin heavy chains

Keyword

3D-structure; Alternative splicing; Cell membrane; Complete proteome; GTPase activation; Membrane; Metal-binding; Polymorphism; Reference proteome; Zinc; Zinc-finger.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

467 AA

Protein Sequence

MATRSCREKA QKLNEQHQLI LSKLLREEDN KYCADCEAKG PRWASWNIGV FICIRCAGIH 60
RNLGVHISRV KSVNLDQWTA EQIQCMQDMG NTKARLLYEA NLPENFRRPQ TDQAVEFFIR 120
DKYEKKKYYD KNAIAITNIS SSDAPLQPLV SSPSLQAAVD KNKLEKEKEK KKEEKKREKE 180
PEKPAKPLTA EKLQKKDQQL EPKKSTSPKK AAEPTVDLLG LDGPAVAPVT NGNTTVPPLN 240
DDLDIFGPMI SNPLPATVMP PAQGTPSAPA AATLSTVTSG DLDLFTEQTT KSEEVAKKQL 300
SKDSILSLYG TGTIQQQSTP GVFMGPTNIP FTSQAPAAFQ GFPSMGVPVP AAPGLIGNVM 360
GQSPSMMVGM PMPNGFMGNA QTGVMPLPQN VVGPQGGMVG QMGAPQSKFG LPQAQQPQWS 420
LSQMNQQMAG MSISSATPTA GFGQPSSTTA GWSGSSSGQT LSTQLWK 467

Gene Ontology

GO:0005737; C:cytoplasm; IEA:Compara.
GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0008060; F:ARF GTPase activator activity; IEA:Compara.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0045648; P:positive regulation of erythrocyte differentiation; IEA:Compara.
GO:0043547; P:positive regulation of GTPase activity; IEA:GOC.
GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro.
GO:2000369; P:regulation of clathrin-mediated endocytosis; IEA:Compara.

Interpro

IPR001164; ArfGAP.

Pfam

PF01412; ArfGap

SMART

SM00105; ArfGap

PROSITE

PS50115; ARFGAP

PRINTS

PR00405; REVINTRACTNG.