CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019107
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 RUN domain-containing protein 1 
Protein Synonyms/Alias
  
Gene Name
 RUNDC1 
Gene Synonyms/Alias
 LP5161 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
183ETQREKQKELILQLKubiquitination[1]
228IIDELIKKLDMNLNEubiquitination[1]
263IVNPARVKEQLVEQLubiquitination[1, 2]
271EQLVEQLKTQIRDLEubiquitination[1]
383RDYSPLLKRLEVSVDubiquitination[1, 2]
393EVSVDRVKQLALRQQubiquitination[1]
419QDLSLGGKDELTMAVubiquitination[1]
428ELTMAVRKELTVAVRubiquitination[1]
495YVESPARKLSQSFALubiquitination[1, 2, 3]
594LSRLSSLKFSLPVDLubiquitination[1, 4]
610VRQLKNIKDAF****ubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
 May play a role as p53/TP53 inhibitor and thus may have oncogenic activity. 
Sequence Annotation
 DOMAIN 421 602 RUN.
 MOD_RES 54 54 Phosphothreonine.
 MOD_RES 71 71 Phosphoserine.
 MOD_RES 75 75 Phosphoserine.  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 613 AA 
Protein Sequence
MAAVEAAAEP VTVVAAVGPK AKDEEEEEEE PLPPCEAVRW APVGAVAEAR PGATAFLEEA 60
TAEEPGAAPG SPPDSPGRTL RRLRAERRRL DSALLALSSH FAQVQFRLRQ VVRGAPAEQQ 120
RLLRELEDFA FRGCPHVLGY EGPGDPASDE GDGLPGDRPW LRGEDQSEQE KQERLETQRE 180
KQKELILQLK TQLDDLETFA YQEGSYDSLP QSVVLERQRV IIDELIKKLD MNLNEDISSL 240
STEELRQRVD AAVAQIVNPA RVKEQLVEQL KTQIRDLEMF INFIQDEVGS PLQTGGGHCE 300
CKAGGKTGNG CSRTGSSRTP PGNSKTKAED VKKVRETGLH LMRRALAVLQ IFAVSQFGCA 360
TGQIPPTLWQ RVQADRDYSP LLKRLEVSVD RVKQLALRQQ PHDHVITSAN LQDLSLGGKD 420
ELTMAVRKEL TVAVRDLLAH GLYASSPGMS LVMAPIACLL PAFSSAPEAM HPWELFVKYY 480
HAKNGRAYVE SPARKLSQSF ALPVTGGTVV TPKQSLLTAI HMVLTEHDPF KRSADSELKA 540
LVCMALNEQR LVSWVNLICK SGSLIEPHYQ PWSYMAHTGF ESALNLLSRL SSLKFSLPVD 600
LAVRQLKNIK DAF 613 
Gene Ontology
  
Interpro
 IPR004012; Run. 
Pfam
 PF02759; RUN 
SMART
 SM00593; RUN 
PROSITE
 PS50826; RUN 
PRINTS