UniProt Accession

 FHL2_HUMAN; Q14192; Q13229; Q13644; Q2I5I4; Q9P294 

Genbank Protein ID

 L42176; U29332; AB038794; DQ307067; BC014397; U60117 

Genbank Nucleotide ID

 AAA85333.1; AAC52073.1; BAA92253.1; ABC25549.1; AAH14397.1; AAC50794.1 

Protein Name

 Four and a half LIM domains protein 2 

Protein Synonyms/Alias

 FHL-2; LIM domain protein DRAL; Skeletal muscle LIM-protein 3; SLIM-3 

Gene Name

 FHL2 

Gene Synonyms/Alias

 DRAL; SLIM3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
139	CQQPIGTKSFIPKDN	ubiquitination	[1]
235	ISGLGGTKYISFEER	ubiquitination	[1]
253	NDCFNCKKCSLSLVG	ubiquitination	[1]
277	ILCPDCGKDI*****	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. 

Sequence Annotation

 DOMAIN 40 92 LIM zinc-binding 1.
 DOMAIN 101 153 LIM zinc-binding 2.
 DOMAIN 162 212 LIM zinc-binding 3.
 DOMAIN 221 275 LIM zinc-binding 4.
 ZN_FING 7 31 C4-type (Potential).
 MOD_RES 238 238 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; LIM domain; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 279 AA 

Protein Sequence

Gene Ontology

 GO:0015629; C:actin cytoskeleton; IDA:HPA.
 GO:0005925; C:focal adhesion; IDA:HPA.
 GO:0031430; C:M band; IEA:Compara.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0030018; C:Z disc; IEA:Compara.
 GO:0050681; F:androgen receptor binding; NAS:UniProtKB.
 GO:0003713; F:transcription coactivator activity; NAS:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0030521; P:androgen receptor signaling pathway; NAS:UniProtKB.
 GO:0055014; P:atrial cardiac muscle cell development; IEA:Compara.
 GO:0044255; P:cellular lipid metabolic process; TAS:Reactome.
 GO:0060347; P:heart trabecula formation; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0001649; P:osteoblast differentiation; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; NAS:UniProtKB.
 GO:0009725; P:response to hormone stimulus; IMP:BHF-UCL.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0055015; P:ventricular cardiac muscle cell development; IEA:Compara. 

Interpro

 IPR001781; Znf_LIM. 

Pfam

 PF00412; LIM 

SMART

 SM00132; LIM 

PROSITE

 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2 

PRINTS