| Tag | Content |
|---|
| CPLM ID | CPLM-013030 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Metal transporter CNNM2 |
Protein Synonyms/Alias | Ancient conserved domain-containing protein 2; mACDP2; Cyclin-M2 |
Gene Name | Cnnm2 |
Gene Synonyms/Alias | Acdp2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 297 | VQNCGTEKEKNYAKR | ubiquitination | [1] | | 413 | GTVYNREKLLEMLRV | ubiquitination | [1] | | 542 | LEEFKKGKSHLAIVQ | ubiquitination | [1] | | 806 | LSDLQFVKISRQQYQ | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+). |
Sequence Annotation | DOMAIN 258 430 DUF21.
DOMAIN 450 511 CBS 1.
DOMAIN 518 584 CBS 2.
CARBOHYD 112 112 N-linked (GlcNAc...). |
Keyword | Alternative splicing; CBS domain; Cell membrane; Complete proteome; Direct protein sequencing; Glycoprotein; Ion transport; Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 875 AA |
Protein Sequence | MIGCGACEPE VKMAGGQAAA ALPTWKMAAR RSLSARGRGV LQAAAGRLLP LLLLSCCWGA 60
GGCTAAGENE ETVIIGLRLE DTNDVSFMEG GALRVSERTR VKLRVYGQNI NNETWSRIAF 120
TEHERRRHTP SERGLGGPAP PEPDSGPQRC GIRTSDIIIL PHIILNRRTS GIIEIEIKPL 180
RKMEKSKSYY LCTSLSTPAL GAGGSGSASG TVGGKGGAGV AGLPPPPWAE TTWIYHDGED 240
TKMIVGEEKK FLLPFWLQVI FISLLLCLSG MFSGLNLGLM ALDPMELRIV QNCGTEKEKN 300
YAKRIEPVRR QGNYLLCSLL LGNVLVNTTL TILLDDIAGS GLVAVVVSTI GIVIFGEIVP 360
QAICSRHGLA VGANTIFLTK FFMMMTFPAS YPVSKLLDCV LGQEIGTVYN REKLLEMLRV 420
TDPYNDLVKE ELNIIQGALE LRTKTVEDVM TPLRDCFMIT GEAILDFNTM SEIMESGYTR 480
IPVFEGERSN IVDLLFVKDL AFVDPDDCTP LKTITKFYNH PLHFVFNDTK LDAMLEEFKK 540
GKSHLAIVQR VNNEGEGDPF YEVLGIVTLE DVIEEIIKSE ILDETDLYTD NRTKKKVAHR 600
ERKQDFSAFK QTDSEMKVKI SPQLLLAMHR FLATEVEAFS PSQMSEKILL RLLKHPNVIQ 660
ELKYDEKNKK APECYLYQRN KPVDYFVLIL QGKVEVEAGK EGMKFEASAF SYYGVMALTA 720
SPVPLSLSRT FVVSRTEVLA AGSPGENKSP PRPCGLNHSD SLSRSDRIDA MTPTLGSSNN 780
QLSSSFLQVY IPDYSVRALS DLQFVKISRQ QYQNALMASR MDKTPQSSDS ENTKIELTLT 840
ELHDGLPDET ANLLNEQNCV SHNKANHSLH SEGAI 875 |
Gene Ontology | GO:0016323; C:basolateral plasma membrane; IDA:MGI. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0010960; P:magnesium ion homeostasis; IEA:Compara. GO:0015693; P:magnesium ion transport; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |