CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017082
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable ATP-dependent RNA helicase DHX37 
Protein Synonyms/Alias
 DEAH box protein 37 
Gene Name
 DHX37 
Gene Synonyms/Alias
 DDX37; KIAA1517 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
232PLPRALAKPAVFIPVubiquitination[1]
425QNPRLFAKPPPVIKVubiquitination[1]
640KYVVDCGKVKKRYYDubiquitination[1]
757PQKAERVKQLQENRLubiquitination[1]
786PVAPRYAKMLALSRQubiquitination[1]
840RARVAQMKRTWAGQGacetylation[2]
950SEEMLEDKWRNAYKTubiquitination[1]
956DKWRNAYKTPLLDDPubiquitination[1]
1093SSPGTMLKTWARLQPubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
 Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G.
 J Cell Biol. 2011 Feb 21;192(4):615-29. [PMID: 21339330] 
Functional Description
  
Sequence Annotation
 DOMAIN 262 429 Helicase ATP-binding.
 DOMAIN 459 716 Helicase C-terminal.
 NP_BIND 275 282 ATP (By similarity).
 MOTIF 372 375 DEAH box.  
Keyword
 ATP-binding; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1157 AA 
Protein Sequence
MGKLRRRYNI KGRQQAGPGP SKGPPEPPPV QLELEDKDTL KGVDASNALV LPGKKKKKTK 60
APPLSKKEKK PLTKKEKKVL QKILEQKEKK SQRAEMLQKL SEVQASEAEM RLFYTTSKLG 120
TGNRMYHTKE KADEVVAPGQ EKISSLSGAH RKRRRWPSAE EEEEEEEESE SELEEESELD 180
EDPAAEPAEA GVGTTVAPLP PAPAPSSQPV PAGMTVPPPP AAAPPLPRAL AKPAVFIPVN 240
RSPEMQEERL KLPILSEEQV IMEAVAEHPI VIVCGETGSG KTTQVPQFLY EAGFSSEDSI 300
IGVTEPRRVA AVAMSQRVAK EMNLSQRVVS YQIRYEGNVT EETRIKFMTD GVLLKEIQKD 360
FLLLRYKVVI IDEAHERSVY TDILIGLLSR IVTLRAKRNL PLKLLIMSAT LRVEDFTQNP 420
RLFAKPPPVI KVESRQFPVT VHFNKRTPLE DYSGECFRKV CKIHRMLPAG GILVFLTGQA 480
EVHALCRRLR KAFPPSRARP QEKDDDQKDS VEEMRKFKKS RARAKKARAE VLPQINLDHY 540
SVLPAGEGDE DREAEVDEEE GALDSDLDLD LGDGGQDGGE QPDASLPLHV LPLYSLLAPE 600
KQAQVFKPPP EGTRLCVVAT NVAETSLTIP GIKYVVDCGK VKKRYYDRVT GVSSFRVTWV 660
SQASADQRAG RAGRTEPGHC YRLYSSAVFG DFEQFPPPEI TRRPVEDLIL QMKALNVEKV 720
INFPFPTPPS VEALLAAEEL LIALGALQPP QKAERVKQLQ ENRLSCPITA LGRTMATFPV 780
APRYAKMLAL SRQHGCLPYA ITIVASMTVR ELFEELDRPA ASDEELTRLK SKRARVAQMK 840
RTWAGQGASL KLGDLMVLLG AVGACEYASC TPQFCEANGL RYKAMMEIRR LRGQLTTAVN 900
AVCPEAELFV DPKMQPPTES QVTYLRQIVT AGLGDHLARR VQSEEMLEDK WRNAYKTPLL 960
DDPVFIHPSS VLFKELPEFV VYQEIVETTK MYMKGVSSVE VQWIPALLPS YCQFDKPLEE 1020
PAPTYCPERG RVLCHRASVF YRVGWPLPAI EVDFPEGIDR YKHFARFLLE GQVFRKLASY 1080
RSCLLSSPGT MLKTWARLQP RTESLLRALV AEKADCHEAL LAAWKKNPKY LLAEYCEWLP 1140
QAMHPDIEKA WPPTTVH 1157 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro. 
Interpro
 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR011709; DUF1605.
 IPR007502; Helicase-assoc_dom.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00270; DEAD
 PF04408; HA2
 PF00271; Helicase_C
 PF07717; OB_NTP_bind 
SMART
 SM00487; DEXDc
 SM00847; HA2
 SM00490; HELICc 
PROSITE
 PS00690; DEAH_ATP_HELICASE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER 
PRINTS