CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037069
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Aspartyl aminopeptidase 
Protein Synonyms/Alias
  
Gene Name
 DNPEP 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
37EAVQTAAKELLKFVNubiquitination[1]
41TAAKELLKFVNRSPSubiquitination[1]
161LAGRVIVKCPTSGRLubiquitination[1]
417REVANKVKVPLQDLMubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Aminopeptidase; Complete proteome; Hydrolase; Metal-binding; Metalloprotease; Protease; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 493 AA 
Protein Sequence
MARSLSIMFV PNSWLNGYHK VAMNGKARKE AVQTAAKELL KFVNRSPSPF HAVAECRNRL 60
LQAGFSELKE TEKWNIKPES KYFMTRNSST IIAFAVGGQY VPGNGFSLIG AHTDSPCLRV 120
KRRSRRSQVG FQQVGVETYG GGIWSTWFDR DLTLAGRVIV KCPTSGRLEQ QLVHVERPIL 180
RIPHLAIHLQ RNINENFGPN TEMHLVPILA TAIQEELEKG TPEPGPLNAV DERHHSVLMS 240
LLCAHLGLSP KDIVEMELCL ADTQPVVLGG AYDEFIFAPR LDNLHSCFCA LQALIDSCAG 300
PGSLATEPHV RMVTLYDNEE VGSESAQGAQ SLLTELVLRR ISASCQHPTA FEEAIPKSFM 360
ISADMAHAVH PNYLDKHEEN HRPLFHKGPV IKVNSKQRYA SNAVSEALIR EVANKVKVPL 420
QDLMVRNDTP CGTTIGPILA SRLGLRVLDL GSPQLAMHSI REMACTTGVL QTLTLFKGFF 480
ELFPSLSHNL LVD 493 
Gene Ontology
 GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
 GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR001948; Peptidase_M18.
 IPR023358; Peptidase_M18_dom2. 
Pfam
 PF02127; Peptidase_M18 
SMART
  
PROSITE
  
PRINTS
 PR00932; AMINO1PTASE.