UniProt Accession

 DEF_MYCPN; P75527 

Genbank Protein ID

 U00089 

Genbank Nucleotide ID

 AAB96235.1 

Protein Name

 Peptide deformylase 

Protein Synonyms/Alias

 PDF; Polypeptide deformylase 

Gene Name

 def 

Gene Synonyms/Alias

 MPN_245; MP587 

Created Date

 July 27, 2013 

Organism

 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 

NCBI Taxa ID

 272634 

Lysine Modification

Position	Peptide	Type	References
202	LNPLFTNKEWKVINP	acetylation	[1]

Reference

 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 

Functional Description

 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity). 

Sequence Annotation

 ACT_SITE 179 179 By similarity.
 METAL 134 134 Iron (By similarity).
 METAL 178 178 Iron (By similarity).
 METAL 182 182 Iron (By similarity).  

Keyword

 Complete proteome; Hydrolase; Iron; Metal-binding; Protein biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 216 AA 

Protein Sequence

Gene Ontology

 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0042586; F:peptide deformylase activity; IEA:HAMAP.
 GO:0006412; P:translation; IEA:HAMAP. 

Interpro

 IPR000181; Fmet_deformylase.
 IPR023635; Peptide_deformylase. 

Pfam

 PF01327; Pep_deformylase 

SMART

  

PROSITE

  

PRINTS

 PR01576; PDEFORMYLASE.