UniProt Accession

 NDK3_MOUSE; Q9WV85; Q9D931; Q9EPA2 

Genbank Protein ID

 AF153449; AF288689; AF288691; AK007399; BC028503 

Genbank Nucleotide ID

 AAD38976.1; AAG02199.1; AAG02201.1; BAB25013.1; AAH28503.1 

Protein Name

 Nucleoside diphosphate kinase 3 

Protein Synonyms/Alias

 NDK 3; NDP kinase 3; DR-nm23; Nucleoside diphosphate kinase C; NDPKC; nm23-M3 

Gene Name

 Nme3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
29	ERTFLAVKPDGVQRR	ubiquitination	[1]
75	HYVELREKPFYSRLV	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis (By similarity). 

Sequence Annotation

 ACT_SITE 135 135 Pros-phosphohistidine intermediate (By
 BINDING 29 29 ATP (By similarity).
 BINDING 77 77 ATP (By similarity).
 BINDING 105 105 ATP (By similarity).
 BINDING 111 111 ATP (By similarity).
 BINDING 122 122 ATP (By similarity).
 BINDING 132 132 ATP (By similarity).  

Keyword

 ATP-binding; Complete proteome; Kinase; Magnesium; Metal-binding; Nucleotide metabolism; Nucleotide-binding; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 169 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004550; F:nucleoside diphosphate kinase activity; IEA:EC.
 GO:0006241; P:CTP biosynthetic process; IEA:InterPro.
 GO:0006183; P:GTP biosynthetic process; IEA:InterPro.
 GO:0006228; P:UTP biosynthetic process; IEA:InterPro. 

Interpro

 IPR001564; Nucleoside_diP_kinase.
 IPR023005; Nucleoside_diP_kinase_AS. 

Pfam

 PF00334; NDK 

SMART

 SM00562; NDK 

PROSITE

 PS00469; NDP_KINASES 

PRINTS

 PR01243; NUCDPKINASE.