CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016732
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tubulin-specific chaperone cofactor E-like protein 
Protein Synonyms/Alias
 Leucine-rich repeat-containing protein 35 
Gene Name
 Tbcel 
Gene Synonyms/Alias
 Lrrc35 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
236LRSISLHKSGLQSWEubiquitination[1]
329ELITKYGKLEPLAEVubiquitination[1]
369DQTVAELKKQLKTLVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Acts as a regulator of tubulin stability (By similarity). 
Sequence Annotation
 REPEAT 73 98 LRR 1.
 REPEAT 99 123 LRR 2.
 REPEAT 124 147 LRR 3.
 REPEAT 152 173 LRR 4.
 REPEAT 175 196 LRR 5.
 REPEAT 201 222 LRR 6.
 REPEAT 228 249 LRR 7.
 DOMAIN 262 303 LRRCT.
 DOMAIN 334 424 Ubiquitin-like.
 MOD_RES 41 41 Phosphoserine.  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Leucine-rich repeat; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 424 AA 
Protein Sequence
MDQPSGRSFM QVLCEKYSPE NFPYRRGPGV GVHVPATPQG SPMKDRLNLP SVLVLNSCGI 60
TCAGDEREIA AFCAHVSELD LSDNKLQDWH EVSKIVSNVP QLEFLNLSSN PLSLSVLERT 120
CAGSFSGVRK LVLNNSKASW ETVHTILQEL PELEELFLCL NDYETVSCPS VCCHSLKLLH 180
ITDNNLQDWT EIRKLGVMFP SLDTLVLANN HLNAIEEPAD SLARLFPNLR SISLHKSGLQ 240
SWEDIDKLNS FPKLEEVRLL GIPLLQPYTT EERRKLVVAR LPSVSKLNGS VVTDGEREDS 300
ERFFIRYYVD VPQEEVPFRY HELITKYGKL EPLAEVDLRP QSSAKVEVHF NDQVEEMSIR 360
LDQTVAELKK QLKTLVQLPT SSMLLYYFDH EAPFGPEEMK YSSRALHSFG IRDGDKIFVE 420
SKTK 424 
Gene Ontology
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; TAS:Reactome. 
Interpro
  
Pfam
  
SMART
  
PROSITE
 PS00299; UBIQUITIN_1
 PS50053; UBIQUITIN_2 
PRINTS